晚期胃肠道间质瘤治疗的研究进展

doi:10.16139/j.1007-9610.2025.05.13

摘要/Abstract

摘要：

KIT或PDGFRA受体酪氨酸激酶功能获得性突变是大多数胃肠道间质瘤(GIST)的关键驱动因素。伊马替尼、舒尼替尼、安罗替尼、瑞戈非尼、瑞派替尼和阿伐替尼等酪氨酸激酶抑制剂的不断开发，极大程度上延长晚期GIST病人的总生存期。本文综述了近年来代表性酪氨酸激酶抑制剂在晚期胃肠道间质瘤治疗中的疗效(包括客观缓解率、疾病稳定率、中位无进展生存期)及常见不良事件，旨在为晚期GIST病人的治疗选择提供临床依据。

关键词: 胃肠道间质瘤, 酪氨酸激酶抑制剂, KIT原癌基因, 血小板衍生生长因子受体α

Abstract:

Gain-of-function mutations in KIT or PDGFRA receptor tyrosine kinase are key drivers of most gastrointestinal stromal tumor (GIST). The continuous development of tyrosine kinase inhibitors, such as imatinib, sunitinib, anlotinib, regorafenib, ripretinib and avapritinib, has greatly improved the overall survival of patients with advanced GIST. This article reviewed the efficacy (including objective response rate, disease stability rate, median progression free survival) and common adverse events of representative tyrosine kinase inhibitors in the treatment of advanced GIST in recent years, aiming to provide a clinical basis for the treatment options of patients with advanced GIST.

Key words: Gastrointestinal stromal tumor(GIST), Tyrosine kinase inhibitor(TKI), KIT proto-onco gene, Platelet-derived growth factor receptor alpha (PDGFRA)

中图分类号:

R735

唐海啸, 张云, 韩刚, 龚航军. 晚期胃肠道间质瘤治疗的研究进展[J]. 外科理论与实践, 2025, 30(05): 456-460.

TANG Haixiao, ZHANG Yun, HAN Gang, GONG Hangjun. Progression in treatment of advanced gastrointestinal stromal tumors[J]. Journal of Surgery Concepts & Practice, 2025, 30(05): 456-460.

图/表 1

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Treatment drug	KIT/platelet derived growth factor alpha mutated gastrointestinal stromal tumors				Platelet derived growth factor alpha D842V mutated gastrointestinal stromal tumors
	First-line: Imatinib^[34]	Second-line: Sunitinib^[35]	Third-line: Regorafenib^[36]	Fourth-line: Avapritinib^[37]	Any: Avapritinib^[38]
Objective response rate (%)	68.1	17.6	7.2	9.4	91.0
Stable disease rate(%)	15.6	Not available	67.8	47.0	9.0
Median progression-free survival (months)	24.0	8.3	5.6	6.3	34.0