Correlation of 5-year metabolic traits changes in elderly patients with chronic non-infectious diseases

Abstract

Abstract:

ObjectiveTo investigate the correlations and 5-year changes of metabolic traits in elderly patients with chronic non-communicable diseases.MethodsBetween January and December 2016, 159 patients with chronic non-infectious diseases were included and followed up until December 2020. Clinical data and biochemical indicators tested in first time (baseline metabolic traits) and every following year were collected. Spearman correlation coefficients were used to analyze correlations among baseline metabolic traits, as well as 5-year changes in metabolic traits.ResultsSpearman correlation analysis showed that systolic blood pressure in baseline cross-sectional analysis was significantly positively correlated with 2 h blood glucose (r=0.371), fasting insulin (r=0.287), C-reactive protein (r=0.379) and serum uric acid (r=0.268) levels (allP<0.05); while it was negatively correlated with high-density lipoprotein (r=-0.308) and apolipoprotein A (r=-0.311) (bothP<0.05). Systolic blood pressure was positively correlated with C-reactive protein level (r=0.305,P<0.05), and negatively correlated with high-density lipoprotein level (r=-0.269,P<0.05). Fasting insulin and 2 h insulin was associated with low density lipoprotein(r=0.349, 0.287), fasting insulin and 2 h insulin were correlated with apolipoprotein B (r=0.290, 0.259), 2 h blood glucose and fasting insulin were positively correlated with serum uric acid (r=0.287 and 0.327, respectively) (allP<0.05). The changes of high-density lipoprotein and apolipoprotein A levels were significantly negatively correlated with the changes of C-reactive protein(r=-0.295, -0.377) and blood uric acid (r=-0.263, -0.262) levels (P<0.05). The changes of low-density lipoprotein and apolipoprotein B levels were significantly positively correlated with the changes of blood uric acid (r=0.258 and 0.257, respectively) (P<0.05).ConclusionsThe changes of blood pressure, glucose traits, lipids profile and inflammatory traits among the elderly patients with chronic non-infectious diseases showed significantly correlation and a synergistic trend.

Key words:The elderly with chronic non-communicable diseases,Metabolic trait,Long-term trend

CLC Number:

R592

LI Yanran, XU Chenying, RONG Lan, LIN Qing. Correlation of 5-year metabolic traits changes in elderly patients with chronic non-infectious diseases[J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(02): 87-91.

Figures/Tables3

代谢指标	基线	随访	差值Δ	P
收缩压（mmHg）	130.00（119.00, 144.00）	125.00（117.00, 138.00）	-4.00（-16.00, 6.00）	<.0001
舒张压（mmHg）	78.00（73.00, 83.00）	74.00（70.00, 79.00）	-3.00（-8.00, 2.00）	<.0001
脉压（mmHg）	70.00（68.00, 77.00）	72.00（70.00, 78.00）	2.00（-1.00, 6.00）	<.0001
空腹血糖（mmol/L）	5.51（5.07, 6.09）	5.38（5.06, 6.38）	-0.07（-0.44, 0.62）	<.0001
2 h血糖（mmol/L）	7.40（6.22, 9.10）	7.86（6.21, 9.85）	0.35（-075, 1.94）	<.0001
糖化血红蛋白（%）	5.80（5.50, 6.10）	5.80（5.50, 6.10）	0.00（-0.75, 1.94）	<.0001
空腹胰岛素（μU/L）	9.98（7.99, 14.28）	9.04（7.15, 12.85）	-0.22（-2.86, 1.45）	<.0001
2 h胰岛素（μU/L）	68.55（31.15, 109.20）	55.86（31.63, 123.90）	2.33（-31.15, 26.10）	<.0001
甘油三酯（mmol/L）	1.51（0.99, 1.96）	1.26（0.97, 1.68）	-0.20（-0.58, 0.10）	<.0001
总胆固醇（mmol/L）	4.72（3.98, 5.52）	4.73（3.93, 5.41）	-0.06（-0.79, 0.41）	<.0001
低密度脂蛋白（mmol/L）	2.76（2.06, 3.57）	2.67（2.16, 3.40）	-0.04（-0.69, 0.31）	<.0001
高密度脂蛋白（mmol/L）	1.29（1.14, 1.60）	1.35（1.17, 1.60）	0.07（-0.03, 0.17）	<.0001
载脂蛋白A（g/L）	1.40（1.27, 1.63）	1.39（1.28, 1.61）	-0.01（-0.08, 0.16）	<.0001
载脂蛋白B（g/L）	0.93（0.80, 1.06）	0.88（0.71, 1.03）	-0.04（-0.69, 0.31）	<.0001
C反应蛋白（mg/L）	2.1（1.6, 2.8）	7.0（5.0, 10.0）	4.9（2.4, 8.1）	<.0001
血肌酐（μmol/L）	77.00（68.00, 84.00）	77.00（70.00, 89.00）	1.00（-4.00, 6.00）	<.0001
血尿酸（μmol/L）	331.00（293.00, 380.00）	343.00（294.00, 390.00）	8.00（-31.00, 39.00）	<.0001
尿微量白蛋白（mg/L）	1.07（1.05, 1.10）	0.68（0.50, 1.08）	-0.50（-0.57, 0.05）	<.0001
尿白蛋白比肌酐（mg/mmol）	2.50（2.50, 2.50）	2.50（0.92, 2.50）	0.00（-1.54, 0.00）	<.0001

	A	B	C	D	E	F	G	H	I	J	K	L	M	N	O	P	Q	R	S
A	1.000	0.558^*	0.433^*	0.083	0.371^*	0.176	0.287^*	0.256	0.056	-0.179	-0.159	-0.308^*	-0.311^*	-0.080	0.379^*	0.142	0.268^*	-0.108	0.230
B	0.558^*	1.000	0.501	0.094	0.243	0.108	0.143	0.058	0.063	0.007	0.022	-0.102	-0.065	-0.010	-0.032	-0.198	0.072	-0.134	0.203
C	0.433^*	0.501^*	1.000	0.049	0.092	0.056	0.040	0.075	0.171	0.097	0.065	-0.089	-0.058	0.076	0.137	-0.150	0.043	-0.100	0.135
D	0.083	0.094	0.049	1.000	0.329^*	0.603^*	0.111	-0.166	0.139	-0.206	-0.129	-0.408^*	-0.318^*	-0.025	0.001	0.005	0.338^*	0.127	-0.035
E	0.371^*	0.243	0.092	0.329^*	1.000	0.516^*	0.197	0.457^*	0.095	-0.063	0.081	-0.304^*	-0.168	0.087	0.340^*	-0.042	0.258^*	-0.016	0.151
F	0.176	0.108	0.056	0.603^*	0.516^*	1.000	0.011	-0.029	0.117	-0.058	0.008	-0.297^*	-0.343^*	0.026	0.116	-0.082	0.124	0.280^*	0.007
G	0.287^*	0.143	0.040	0.111	0.197	0.011	1.000	0.581^*	0.123	-0.109	-0.020	-0.330^*	-0.193	0.026	-0.033	0.094	0.476^*	-0.116	-0.012
H	0.256	0.058	0.075	-0.166	0.457^*	-0.029	0.581^*	1.000	0.135	0.058	0.193	-0.161	-0.063	0.175	0.199	0.039	0.257	-0.024	-0.055
I	0.056	0.053	0.171	0.139	0.095	0.117	0.123	0.135	1.000	0.401^*	0.239	-0.343	-0.156	0.539	0.074	-0.094	0.177	-0.042	0.025
J	-0.179	0.007	0.097	-0.206	-0.063	-0.058	-0.109	0.058	0.401^*	1.000	0.827^*	0.181	0.216	0.810	-0.047	-0.178	-0.138	-0.020	-0.096
K	-0.159	0.022	0.065	-0.129	0.081	0.008	-0.020	0.193	0.239	0.827^*	1.000	-0.056	0.006	0.813	-0.084	-0.136	0.007	-0.054	-0.168
L	-0.308^*	-0.102	-0.089	-0.408^*	-0.304^*	-0.297^*	-0.330^*	-0.161	-0.343^*	0.181	-0.056	1.000	0.812^*	-0.165	-0.094	-0.156	-0.469^*	0.016	-0.110
M	-0.311^*	-0.065	-0.058	-0.318^*	-0.168	-0.343^*	-0.193	-0.063	-0.156	0.216	0.006	0.812^*	1.000	-0.014	-0.102	-0.256	-0.339^*	-0.050	-0.073
N	-0.080	-0.010	0.076	-0.025	0.087	0.026	0.026	0.175	0.539^*	0.810^*	0.813^*	-0.164	-0.014	1.000	-0.026	-0.043	0.058	0.048	-0.152
O	0.379^*	-0.032	0.137	0.001	0.340^*	0.116	-0.033	0.199	0.074	-0.047	-0.084	-0.094	-0.102	-0.025	1.000	0.112	0.039	0.020	0.012
P	0.142	-0.198	-0.150	0.005	-0.042	-0.082	0.094	0.039	-0.094	-0.178	-0.136	-0.156	-0.256	-0.043	0.112	1.000	0.456^*	0.136	-0.069
Q	0.268^*	0.072	0.043	0.338^*	0.258^*	0.124	0.476^*	0.257^*	0.177	-0.138	0.007	-0.469^*	-0.339^*	0.058	0.039	0.456^*	1.000	-0.080	-0.065
R	-0.108	-0.134	-0.100	0.127	-0.016	0.280^*	-0.116	-0.024	-0.042	-0.020	-0.054	0.016	-0.050	0.048	0.020	0.136	-0.080	1.000	-0.277^*
S	0.230	0.203	0.135	-0.035	0.151	0.007	-0.012	-0.055	0.025	-0.096	-0.168	-0.110	-0.073	-0.152	0.012	-0.069	-0.065	-0.277^*	1.000

	△A	△B	△C	△D	△E	△F	△G	△H	△I	△J	△K	△L	△M	△N	△O	△P	△Q	△R	△S
△A	1.000	0.408^*	0.302^*	-0.122	0.088	0.214	0.119	-0.062	0.056	0.001	0.068	-0.269^*	-0.216^*	0.037	0.305^*	0.079	0.051	0.006	0.041
△B	0.408^*	1.000	0.506^*	0.069	0.173	0.224	0.098	0.092	0.094	0.131	0.166	-0.209	-0.045	0.024	-0.001	-0.177	-0.068	-0.061	0.052
△C	0.302^*	0.506^*	1.000	-0.078	-0.010	0.146	-0.104	-0.034	0.108	0.236	0.083	0.011	0.071	0.092	0.073	-0.038	0.051	-0.094	-0.174
△D	-0.122	0.069	-0.078	1.000	0.434^*	0.416^*	0.253	0.172	-0.097	0.069	0.100	0.107	0.023	0.045	-0.192	-0.109	0.076	0.013	0.039
△E	0.088	0.173	-0.010	0.434^*	1.000	0.430	0.213	0.570^*	0.003	0.030	0.184	-0.113	-0.084	0.172	-0.028	-0.051	0.287^*	0.204	-0.047
△F	0.214	0.224	0.146	0.416^*	0.430^*	1.000	0.179	0.150	-0.042	0.004	0.207	-0.203	-0.094	0.149	0.202	-0.103	0.125	0.129	-0.023
△G	0.119	0.098	-0.104	0.253	0.213	0.179	1.000	0.468^*	-0.181	0.163	0.349^*	-0.058	0.035	0.290^*	-0.051	0.000	0.327^*	-0.071	0.213
△H	-0.062	0.092	-0.034	0.172	0.570^*	0.150	0.468^*	1.000	-0.033	0.136	0.287^*	-0.050	0.055	0.259^*	-0.215	0.003	0.192	0.216	0.006
△I	0.056	0.094	0.108	-0.097	0.003	-0.042	-0.181	-0.033	1.000	0.166	0.182	-0.041	0.073	0.166	-0.078	0.078	-0.158	-0.046	-0.140
△J	0.001	0.131	0.236	0.069	0.030	0.004	0.163	0.136	0.166	1.000	0.848^*	0.256	0.252	0.695^*	-0.213	0.034	0.188	-0.061	0.103
△K	0.068	0.166	0.083	0.100	0.184	0.207	0.349^*	0.287^*	0.182	0.848^*	1.000	0.034	0.120	0.824^*	-0.156	0.023	0.258^*	-0.071	0.123
△L	-0.269^*	-0.209	0.011	0.107	-0.113	-0.203	-0.058	-0.050	-0.041	0.256	0.034	1.000	0.725^*	0.022	-0.295^*	0.020	-0.263^*	-0.173	0.081
△M	-0.216	-0.045	0.071	0.023	-0.084	-0.094	0.035	0.055	0.073	0.252	0.120	0.725^*	1.000	0.101	-0.377^*	0.169	-0.262^*	-0.165	-0.001
△N	0.037	0.024	0.092	0.045	0.172	0.149	0.290^**	0.259	0.166	0.695^*	0.824^*	0.022	0.101	1.000	-0.138	0.048	0.257	0.070	0.159
△O	0.305^*	-0.001	0.073	-0.192	-0.028	0.202	-0.051	-0.215	-0.078	-0.213	-0.156	-0.295^*	-0.377^*	-0.138	1.000	-0.024	0.052	-0.046	0.092
△P	0.079	-0.177	-0.038	-0.109	-0.051	-0.103	0.000	0.003	0.078	0.034	0.023	0.020	0.169	0.048	-0.024	1.000	-0.022	0.157	-0.062
△Q	0.051	-0.068	0.051	0.076	0.287^*	0.125	0.327^*	0.192	-0.158	0.188	0.258^*	-0.263^*	-0.262^*	0.257^*	0.052	-0.022	1.000	-0.050	-0.229
△R	0.006	-0.061	-0.094	0.013	0.204	0.129	-0.071	0.216	-0.046	-0.061	-0.071	-0.173	-0.165	0.070	-0.046	0.157	-0.050	1.000	-0.064
△S	0.041	0.052	-0.174	0.039	-0.047	-0.023	0.213	0.006	-0.140	0.103	0.123	0.081	-0.001	0.159	0.092	-0.062	-0.229	-0.064	1.000

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