Abstract:Objective:To evaluate the ultrasonographic (US) features of non-mass ductal carcinomain situ(DCIS) of the breast and their correlation with clinical, pathological characteristics and biomarkers.Methods:A total of 68 non-mass DCIS patients were enrolled in this study. Clinical and pathological characteristics, biomarkers including estrogen receptor(ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 index and preoperative ultrasound imaging data were collected. The sonographic features were classified as four types: type Ⅰ: ductal type; type Ⅱ: glandular type; type Ⅲ: calcification type; type Ⅳ: architectural distortion type.Correlations between various US features and clinicopathological characteristics, biomarkers were analyzed.Results:For US, type Ⅰ was 21cases (30.9%); type Ⅱ 10 cases（14.7%）, type Ⅲ 31 cases (45.6%), and type Ⅳ 6 cases(8.8%). There were no significant differences in age, menopausal status, sentinel lymph node metastasis, clinical symptoms, ER, PR and Ki-67 index in the 4 groups. Type Ⅰ groupwas more likely to have low grade DCISand HER2 negative expression, and type Ⅲ groupwas more likely to have HER2 positive expression (allP<0.05). Low and intermediate grade DCIS, HER2 negative expressionwere associated significantly withtype I (P<0.05). High grade DCIS and HER2 positive expressionwere associated significantly with typeⅢ (P<0.05).Conclusions:Our findings suggest that some of theultrasound features of non-mass DCIS are associated with the histopathologic characteristics andbiomarkers.

Key words:Non-mass breast cancer,Ductal carcinoma in situ ,Sonography,Clinicopathological characteristics,Biomarker