Combining the weighted amplitude wave superposition method and the autoregression method, a novel mixture simulation technique that can simulate the time histories of 3D wind velocity series was produced. The wind velocity time series were converted to the time series of 3D wind loadings. For a typical tower crane tower, the parametric mechanical model was established. The analysis of wind-induced vibration responses was conducted by Newmarkβ approach. After obtaining the time histories of the stresses for structural hotspots, the method of S-N curve was used to study the effects of structural fatigue damage. The results show that the time history curves of structural windinduced displacement, velocity and acceleration of each node on the tower are stable respectively and structural wind-induced displacement has certain periodicity. The deformation and fatigue damage on both ends of the boom and the top of the tower are relatively greater. These results are expected to provide reference for the windresistant design of tower structures.