Journal of Tissue Engineering and Reconstructive Surgery››2014,Vol. 10››Issue (4): 218-221.doi:10.3969/j.issn.1673-0364.2014.04.013

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Research Progress of Vascular Abnormalities in NF1

Gao Yang,HU Jiaojie,LIN Xiaoxi

  1. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine;
  • Published:2020-07-23

Abstract:Neurofibromatosis type 1 is a common autosomal dominant condition caused by heterozygous mutations of the NF1 gene. The most frequent clinical manifestations are alterations of skin pigmentation and benign neurofibromas, but patients with NF1 may also develop nervous system tumors, skeletal abnormalities, or vascular disease. Vascular abnormalities is a common complication of NF1 and may lead to a high morbidity and mortality. The new findings of vascular abnormalities NF1were reviewed in this paper.

Key words:Neurofibromatosis type 1,Vascular abnormalities,Pathogenesis,Pathology,Therapy

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