Study on correlationship between circulating tumor cells and pathological staging of gastric cancer

Abstract

Abstract:

ObjectiveTo study the correlationship between circulating tumor cell (CTC) detected preoperatively and pathological staging of gastric cancer and the effect of detection of CTC on prediction of pathological staging.MethodsThe data of 30 cases with gastric cancer subjected to radical surgery in Ruijin Hospital North from January 2016 to December 2017 were collected. All cases had the detection of CTC preoperatively. The correlationship between the amount with subtype of CTC and pathological staging postoperatively were analyzed.ResultsThe amount and subtype of CTC detected preoperatively were correlated with N stage of gastric cancer, however, which were not correlated with T stage. The amount of interstitial CTC was correlated with both TNM stage and N stage of gastric cancer closely.ConclusionsThe preoperative CTC was correlated with the postoperative pathological staging of gastric cancer which would be helpful to predict the clinical prognosis of gastric cancer.

Key words:Gastric cancer,Circulating tumor cell,TNM stage

CLC Number:

R735.2

YAN Xiaowei, LIU Kun, HU Jiele, JIANG Songyao, XIANG Ming. Study on correlationship between circulating tumor cells and pathological staging of gastric cancer[J]. Journal of Surgery Concepts & Practice, 2020, 25(01): 56-59.

TNM分期	CTC阳性率	间质型CTC阳性率	上皮型CTC阳性率	混合型CTC阳性率
Ⅰ期（n=3）	66.6%（2/3）	33.3%（1/3）	33.3%（1/3）	33.3%（1/3）
Ⅱ期（n=7）	71.4%（5/7）	42.8%（3/7）	42.8%（3/7）	42.8%（3/7）
Ⅲ期（n=20）	90.0%（18/20）	65.0%（13/20）	10.0%（2/20）	25.0%（5/20）
总计（n=30）	83.3%（25/30）	56.6%（17/30）	20.0%（6/30）	30.0%（9/30）

项目			CTC总数	上皮型CTC	间质型CTC
T分期	30	相关系数	-0.111	-0.283	-0.075
		P	0.559	0.130	0.694
N分期	30	相关系数	0.246	0.006	0.354
		P	0.190	0.974	0.040^a)
淋巴结转移（阳性/阴性）	30	相关系数	0.380	0.146	0.350
		P	0.038^a)	0.440	0.041^a)
TNM分期（Ⅰ/Ⅱ/Ⅲ）	30	相关系数	0.180	-0.163	0.348
		P	0.340	0.389	0.042^a)

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Study on correlationship between circulating tumor cells and pathological staging of gastric cancer

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