Effect of hyperlipidemia on prognosis of the patients with hepatitis B related hepatocellular carcinoma

Abstract

Abstract:

ObjectiveTo explore the effect of hyperlipidemia and lipid-lowering therapy on the prognosis of postoperative patients with hepatitis B related hepatocellular carcinoma.MethodsThe clinical data of the patients with hepatitis B related hepatocellular carcinoma who were operated in our hospital from January 2012 to January 2021 were retrospectively collected. The effect of blood lipid level and related lipid-lowering therapy on the prognosis of postoperative patients with hepatitis B related hepatocellular carcinoma was analyzed.ResultsAmong 166 patients with hepatitis B related hepatocellular carcinoma, there were 63 cases had hyperlipidemia, of which 33 cases were treated by statins. The median postoperative disease free survival time in the hyperlipidemia group was significantly lower than that in the normal blood lipid group (24.8 monthsvs.38.5 months,P<0.05), and the median overall survival time in the hyperlipidemia group was also significantly lower than that in the normal blood lipid group (30.1 monthsvs.44.5 months,P<0.05). There was no statistically significant difference in prognosis between the patients with hyperlipidemia who used statins or not. The median disease free survival time was 23.4 monthsvs.26.3 months, and the median overall survival time was 29.7 monthsvs.30.3 months.ConclusionsHyperlipidemia is a risk factor for disease free survival and overall survival after surgery in the patients with hepatitis B related hepatocellular carcinoma. The use of statins alone in hyperlipidemia patients cannot reduce the risk of recurrence and prolong survival time.

Key words:Hyperlipidemia,Hepatocellular carcinoma,Hepatitis B related,Lipid-lowering treatment,Statin,Prognosis

CLC Number:

SONG Qingjie, TANG Juanjuan, ZHAO Jianquan, SONG hui, YANG Jun. Effect of hyperlipidemia on prognosis of the patients with hepatitis B related hepatocellular carcinoma[J]. Journal of Surgery Concepts & Practice, 2024, 29(02): 143-147.

Figures/Tables5

Tab 1

Relationship between hyperlipidemia and clinical pathological characteristics [n(%)]

Clinical pathological characteristics	Hyperlipidemia
Clinical pathological characteristics	Total	No	Yes	χ²value	Pvalue
Age (years)				0.094	0.759
≤50	22	13(59.1)	9(40.9)
>50	144	90(62.5)	54(37.5)
Gender				0.889	0.346
Man	114	68(59.6)	46(40.4)
Woman	52	35(67.3)	17(32.4)
Tumor diameter（cm）				0.019	0.889
≤5	99	61(61.6)	38(38.4)
>5	67	42(62.7)	25(37.3)
Microvascular cancer thrombus				2.371	0.124
Yes	59	32(54.2)	27(45.8)
No	107	71(66.4)	36(33.6)
TNM stage				0.989	0.320
Ⅰ	69	43(62.3)	26(37.7)
Ⅱ+Ⅲ	97	60(61.9)	37(38.1)

Tab 1

Item	Hyperlipidemia group (n=63)	Normal blood lipid group (n=103)	χ²/tvalue	Pvalue
Accumulated 1-year survival rate	61(96.8)	103(100)
Accumulated 3-year survival rate	47(74.6)	83(80.6)	750	0.000
Accumulated 5-year survival rate	28（44.4）	53（51.5）
OS (months)	30.1±11.9	44.5±15.6	-6.708	0.000

Tab 2

Item	Hyperlipidemia group (n=63)	Normal blood lipid group (n=103)	χ²/tvalue	Pvalue
Accumulated 1-year recurrence rate	16(25.4)	11(10.7)
Accumulated 3-year recurrence rate	35(55.6)	53(51.5)	452	0.000
Accumulated 5-year recurrence rate	45（71.4）	66（64.1）
DFS (months)	24.8±10.9	38.5±18.5	-5.335	0.000

Tab 3

Fig 1

Fig 2

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