Effects and safety of continuous infusion of cisatracurium in laparoscopic abdominal surgery

Abstract

Abstract:

ObjectiveTo explore the effects and safety of continuous infusion of cisatracurium in laparoscopic abdominal surgery.MethodsNinety patients undergoing elective laparoscopic abdominal surgery in Gubei Branch of Ruijin Hospital from January 2019 to January 2020 were randomly divided into continuous infusion group (n=45) and intermittent infusion group (n=45). Parameters including dosage of cisatracurium, onset time, lack of muscle relaxant occurrences, extubation time, recovery index, which was stimulation with train of four(TOF) and T1 recovery from 25% to 75%, TOF 70% (recovery time for 70% from drug withdrawal to TOF), TOF 90%(recovery time for 90% from drug withdrawal to TOF), both mean arterial pressure and heart rate during anesthesia and during induction, and adverse reactions were compared between two groups.ResultsThere was no significant difference in onset time of cisatracurium between two groups(P=0.102). Lack of muscle relaxant occurrences(P=0.003) and dosage of cisatracurium (P<0.001) in continuous infusion group was significantly lower than those in intermittent infusion group. There was no significant difference in extubation time between two groups (P=0.095). Recovery index, TOF 70% and TOF 90% in continuous infusion group were significantly lower than those in intermittent infusion group (P<0.001). There was no significant difference in both mean arterial pressure and heart rate during anesthesia and during induction(P>0.05) and in the incidence of adverse reactions(P>0.05) between two groups.ConclusionsCompared with intermittent infusion, continuous infusion of cisatracurium in laparoscopic abdominal surgery could have more effect of muscle relaxation, reduce the dosage of cisatracurium, shorten recovery index and reduce adverse reactions.

Key words:Cisatracurium,Continuous infusion,Laparoscopic abdominal surgery

CLC Number:

R614.2

ZHU Qianlin, LI Kai, ZI Yuqiang, JIN Weifang. Effects and safety of continuous infusion of cisatracurium in laparoscopic abdominal surgery[J]. Journal of Surgery Concepts & Practice, 2021, 26(03): 244-248.

Figures/Tables5

项目	持续输注组（n=45）	间断输注组（n=45）	t/χ²值	P值
性别男	27	26	χ²=3.568	0.054
女	18	19
平均年龄（岁）	51.47±8.37	41.46±8.38	t=1.252	0.092
BMI（kg/m²）	22.84±2.36	22.34±2.64	t=0.874	0.312
ASA分级 Ⅱ级	30	29	χ²=1.953	0.076
Ⅲ级	15	16

项目	持续输注组（n=45）	间断输注组（n=45）	t/χ²值	P值
手术时间（min）	158.67±39.12	172.83±43.51	t=1.6234	0.946
顺阿曲库铵用药量（mg）	37.32±4.63	45.15±5.14	t=14.824	<0.001
起效时间（min）	3.39±0.56	3.51±0.58	t=1.234	0.102
肌肉松弛不足发生次数	5（2~6）	8（4~9）	χ²=5.385	0.003

项目	持续输注组（n=45）	间断输注组（n=45）	t值	P值
拔管时间（min）	54.81±11.61	54.68±11.63	1.325	0.095
恢复指数（min）	14.56±2.14	19.35±2.61	10.314	<0.001
TOF70%（min）	47.23±10.82	52.31±8.53	11.237	<0.001
TOF90%（min）	28.31±3.56	35.24±3.76	10.328	<0.001

项目	持续输注组（n=45）	间断输注组（n=45）	t值	P值
平均动脉压（mmHg）麻醉期	92.16±4.72	92.15±4.81	1.021	0.314
诱导期	78.92±4.15^a)	78.89±4.18^a)	1.231	0.205
心率（次/min）麻醉期	78.95±11.02	79.05±10.96	0.952	0.462
诱导期	78.63±10.95	78.86±11.01	0.854	0.521

项目	持续输注组（n=45）	间断输注组（n=45）	χ²值	P值
面色潮红	1	0	-	-
睁眼困难	1	1	-	-
拔管后乏力	0	1	-	-
总发生率（%）	2（4.44）	2（4.44）	1.125	0.214

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