Relationship between Cortactin expression level and tumor budding in colorectal cancer

Abstract

Abstract:ObjectiveTo evaluate Cortactin expression level in the patients with colorectal cancer(CRC) and tumor budding related with the clinical characteristics.MethodsThe expression of Cortactin and tumor budding levels were detected in 97 CRC patients and the correlations of Cortactin and tumor budding with clinical characteristics were determined.ResultsCortactin expression level was significantly related with T stage(P=0.017) and N stage(P<; 0.001) of CRC patients. The patients with higher Cortactin expression level were younger than those with lower Cortactin expression (P=0.043). The tumor budding level was significantly related with T stage (P=0.031), plasma CEA level (P=0.038) and the risk factors of CRC (P=0.008). There was relationship between Cortactin level and tumor budding level in patients with CRC(P=0.011).ConclusionsCortactin expression would be related significantly with the tumor budding of CRC patients. Higher expression of Cortactin suggests the patients poorer prognostic by the mechanism that Cortactin promotes tumor budding and progression of CRC.

Key words:Colorectal cancer,Cortactin,Tumor budding

CLC Number:

LIU Kun, LUO Fangxiu, FANG Xuqian, SHI Yiqing, JIANG Yimei, CHEN Peizhan, ZHAO Ren. Relationship between Cortactin expression level and tumor budding in colorectal cancer[J]. Journal of Surgery Concepts & Practice, 2018, 23(05): 425-429.

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