Safety and efficacy of carbon nanoparticles in operation for papillary thyroid carcinoma

Abstract

Abstract:ObjectiveTo evaluate the safety and clinical efficacy of carbon nanoparticles (CN) as a tracer in surgical operation for papillary thyroid carcinoma patients with a history of thyroid resection.MethodsA retrospective analysis was performed using the clinical data of 53 cases with thyroid papillary carcinoma who had a history of thyroid resection receiving total thyroidectomy combined with lymph node dissection. Twenty-seven cases had CN intra-operative treatment as CN group and 26 cases as control group without CN.ResultsThe lymph node dissection was much more in CN group than in control group (P<0.01). However, there was no difference in the dissection of metastatic lymph node (P=0.077). A total of 176(73.33%) were stained black in 240 dissected lymph nodes of CN group, among which 42(23.86%) lymph nodes were metastatic. Pathologic examination revealed that there were parathyroid in resection specimens from 3 cases in CN group compared with 9 cases in control group (P=0.041). Three cases with hypocalcemia was found in CN group and 10 cases in control group on the postoperative day(P=0.021). However, postoperative hoarseness had no statistical difference between CN group and control group (P=0.280).ConclusionsUsing CN during the operation of papillary thyroid carcinoma would be beneficial to the patients with history of thyroid resection reducing parathyroid injury and keeping serum calcium and phosphorus stable.

Key words:Papillary thyroid carcinoma,Reoperation,Carbon nanoparticles,Complications

CLC Number:

R736.1

FENG Haoran, KUANG Jie, CHENG Xi, JIN Zhijian, YANG Weiping, QIU Weihua, TAN Jian. Safety and efficacy of carbon nanoparticles in operation for papillary thyroid carcinoma[J]. Journal of Surgery Concepts & Practice, 2018, 23(01): 48-51.

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