功能性胰腺神经内分泌肿瘤综合诊治策略（附3例报告）

doi:10.16139/j.1007-9610.2025.05.10

外科理论与实践 ›› 2025, Vol. 30 ›› Issue (05): 438-443.doi: 10.16139/j.1007-9610.2025.05.10

功能性胰腺神经内分泌肿瘤综合诊治策略（附3例报告）

计蓓, 商正晔, 庹必光, 刘雪梅()

遵义医科大学附属医院消化病医院遵义医科大学附属医院消化内科，贵州遵义 563000

收稿日期:2025-06-29 出版日期:2025-09-25 发布日期:2025-12-09
通讯作者: 刘雪梅，E-mail: onlyoneliuxuemei@163.com
基金资助:
国家自然科学基金(82470540);国家自然科学基金(32460215);贵州省科技计划项目(黔科合平台人才-HZJD[2021]001);贵州省科技计划项目(黔科合基础-ZK[2023]重点059);贵州省科技计划项目(黔科合平台人才-CXTD[2023]001);贵州省高层次创新型人才“百层次人才”计划(黔科合平台人才-GCC[2023]043)

Comprehensive diagnosis and treatment strategy for functional pancreas neuroendocrine neoplasm： a report of 3 cases

JI Bei, SHANG Zhengye, TUO Biguang, LIU Xuemei()

Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Guizhou Zunyi 563000, China

Received:2025-06-29 Online:2025-09-25 Published:2025-12-09

摘要/Abstract

摘要：

功能性神经内分泌肿瘤能分泌激素，引发复杂多变的临床症状，诊治难度较大，早期识别与规范诊疗对改善预后尤为重要。本文汇总3例临床上稍常见的功能性胰腺神经内分泌肿瘤病例，总结其诊断要点与规范化诊疗路径，以期为该类罕见肿瘤的早期识别、多学科诊疗协作和个体化治疗提供参考。

关键词: 神经内分泌肿瘤, 功能性胰腺神经内分泌肿瘤, 胰高血糖素瘤, 胰岛素瘤, 胰腺血管活性肠肽瘤

Abstract:

Functional neuroendocrine neoplasm, which secrete hormones and lead to diverse clinical symptoms, pose significant challenges in diagnosis and treatment. Early identification and standardized management are crucial for improving patient prognosis. This article summarized three clinically relatively common cases of Functional pancreatic neuroendocrine neoplasm (F-pNENs), focusing on analyzing their diagnostic key points and standardized therapeutic pathways. It aimed to provide reference for early clinical identification of rare tumors and improvement of standardized multidisciplinary diagnosis and treatment as well as personalized treatment strategies.

Key words: Neuroendocrine neoplasm, Functional pancreatic neuroendocrine neoplasm (F-pNEN), Glucagonoma, Insulinoma, Vasoactive intestinal peptide tumor (VIPoma)

中图分类号:

R735.9

计蓓, 商正晔, 庹必光, 刘雪梅. 功能性胰腺神经内分泌肿瘤综合诊治策略（附3例报告）[J]. 外科理论与实践, 2025, 30(05): 438-443.

JI Bei, SHANG Zhengye, TUO Biguang, LIU Xuemei. Comprehensive diagnosis and treatment strategy for functional pancreas neuroendocrine neoplasm： a report of 3 cases[J]. Journal of Surgery Concepts & Practice, 2025, 30(05): 438-443.

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Time	Blood glucose （mmol/L）	Serum insulin （μIU/mL）	Serum C-peptide （nmol/L）
Fasting	9.5	25	2.2
1-hour postprandial	16.13	65	3.8
2-hour postprandial	14.26	50	3.0
3-hour postprandial	12.91	40	2.5

Time	Blood glucose （mmol/L）	Serum insulin （μIU/mL）	Serum C-peptide （nmol/L）
Fasting	2.64	65	2.8
1-hour postprandial	7.56	118	3.9
2-hour postprandial	5.46	97	3.2
3-hour postprandial	3.82	73	3.0

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功能性胰腺神经内分泌肿瘤综合诊治策略（附3例报告）

Comprehensive diagnosis and treatment strategy for functional pancreas neuroendocrine neoplasm： a report of 3 cases

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