外科理论与实践››2020,Vol. 25››Issue (05): 447-451.doi:10.16139/j.1007-9610.2020.05.020
陈鹏, 李涛(
)
收稿日期:2019-09-16出版日期:2020-09-25发布日期:2022-07-27通讯作者:李涛 E-mail:transplant@126.com作者简介:陈鹏,综述|李涛,审校基金资助:
CHEN Peng, LI Tao()
Received:2019-09-16Online:2020-09-25Published:2022-07-27中图分类号:
陈鹏, 李涛. 胞外囊泡携带的非编码RNA在肝癌发生、发展中的作用[J]. 外科理论与实践, 2020, 25(05): 447-451.
CHEN Peng, LI Tao. Non-coding RNA within extracellular vesicle in pathogenesis of hepatocellular carcinoma[J]. Journal of Surgery Concepts & Practice, 2020, 25(05): 447-451.
表1
ncRNA在肝癌发生、发展中的作用
| ncRNA | 染色体定位 | 作用 |
|---|---|---|
| miR-196b-5p↑[
|
chr6 | 促进肿瘤的血管和神经侵袭,增大肿瘤体积 |
| miR-885-5p↓[
|
chr2 | 作用于HK2-3’UTR,Warburg效应影响乳酸代谢,抑制肿瘤细胞的糖酵解 |
| miR-122↓[
|
chr18q21.31 | 靶向调控IGF-1R作用于RAS/RAF/ERK信号通路,导致肝癌细胞对索拉非尼耐药 |
| miR‐26b↑[
|
chr2q35 | 抑制ZNRD-1转录活性,激活Wnt/β-catenin信号通路,促进肿瘤的增殖 |
| miR -26a↑[
|
chr3p22.2 | 靶向抑制人肝癌的Mcl1,诱导p53介导的线粒体凋亡 |
| miR-210↑[
|
chr11p15.5 | 诱导内皮细胞分化,增加血管密度,促进肝癌细胞增殖 |
| miR-638↓[
|
chr17 | 肿瘤标志物,提示预后较差 |
| miR-148b↑[
|
chr12q13.13 | 抑制肿瘤中CSF1产生和释放,抑制巨噬细胞向肿瘤组织浸润 |
| miR-21↑[
|
chr17q23.1 | 作用于PTEN,激活PDK1/AKT信号通路,肝细胞星形细胞转化为癌相关成纤维细胞 |
| miR-25-5p↑[
|
chr7q22.1 | 下调LRRC7蛋白的表达来增强肿瘤细胞的跨内皮运动能力 |
| lncRNA HULC↑[
|
chr6p24.3 | 抑制p18的活性,促性肿瘤增殖 |
| lncRNA-ATB↑[
|
chr14 | 通过IL-11以及STAT3信号通路促进肿瘤侵袭、转移 |
| lncRNA-HOTAIR↑[
|
chr12q13.13 | 在多种肿瘤组织中过表达,与多种肿瘤增殖有关 |
| lncRNA-HEIH↑[
|
chr14q32.3 |
与EZH2的增强子相互作用,抑制细胞周期蛋白依赖蛋白激酶抑制剂EZh2目标基因p15、p16和p57的活性 |
| lncRNA -FAL1↑[
|
chr4 |
作为分子海绵结合miR-1236,抑制HDAC3与SENP1的表达,调节缺氧导致的上皮细胞-间充质转化和细胞增殖 |
| lncRNA-UBE2CP3↑[
|
chr4q12 | 通过ERK1/2/HIF-1α/VEGFA通路促进VEGFA表达而增强肿瘤血管侵袭性 |
| lncRNA-OGFRP1↓[
|
chr22q13.2 | 下调 AKT/mTOR信号通路抑制肝癌 |
| lncRNA-PTTG3P[
|
chr8p13.1 | 激活PTTG1与PI3K/AKT信号通路调控肿瘤生长 |
| lncRNA-00364[
|
chr13q21.32 | 调整p-STAT3-IFIT2抑制肝癌 |
| lncRNA ZEB1-AS1↑ lncRNA ZFAS1↑[ |
chr10p11.22 chr20q13.13 |
在肝癌细胞系及肝癌组织中表达均明显上调,通过不同分子机制参与肝癌侵袭、转移 |
| lncRNA-TUC339↑[
|
chr12 | EV介导lncRNA转移,进而调节肿瘤细胞的局部微环境 |
| lncRNA-linc-VLDLR[
|
chr9p24.2 | 有助于影响细胞内应激反应水平,与肝癌细胞的化疗耐药相关 |
| lncRNA-linc-RoR[
|
chr18q21.31 | 参与肝癌缺氧机制的信号调节 |
| lncRNA CACNA1G-AS1[
|
chr17q21.33 | 表达产物竞争性地与miR-2392结合,提升肝癌的转化 |
| lncRNA MAGI2-AS3[
|
chr7q21.11 | 作为miR-374b-5p的互补双链,竞争性抑制miR-374b-5p的表达水平阻断肝癌转化 |
| lncRNA-SNHG5↑[
|
chr6q14.3 |
竞争性结合miR-26a-5p,调节GSK3β的表达,激活Wnt/β-catenin通路,诱导上皮细胞-间充质转化 |
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