外科理论与实践››2018,Vol. 23››Issue (02): 173-177.doi:10.16139/j.1007-9610.2018.02.019
周晓琳, 王正廷 综述, 钟捷 审校
收稿日期:2018-01-04出版日期:2018-03-25发布日期:2020-07-25通讯作者:钟捷,E-mail: jimmyzj64@medmail.com.cn
Received:2018-01-04Online:2018-03-25Published:2020-07-25| [1] Goldoni S, Iozzo RA, Kay P, et al.A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity[J]. Oncogene,2007, 26(3):368-381. [2] Yousefi M, Li N, Nakauka-Ddamba A, et al.Msi RNA-binding proteins control reserve intestinal stem cell quiescence[J]. J Cell Biol,2016,215(3):401-413. [3] van der Flier LG, Haegebarth A, Stange DE, et al. OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells[J]. Gastroenterology,2009,137(1):15-17. [4] Gracz AD, Ramalingam S, Magness ST.Sox9 expression marks a subset of CD24-expressing small intestine epi-thelial stem cells that form organoids [5] Schepers AG, Snippert HJ, Stange DE, et al.Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas[J]. Science,2012,337(6095):730-735. [6] Barker N, Clevers H.Lineage tracing in the intestinal epithelium[J]. Curr Protoc Stem Cell Biol,2010,5(4):1-11. [7] Yan KS, Chia LA, Li X, et al.The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations[J]. Proc Natl Acad Sci U S A,2012,109(2):466-471. [8] Berndt JD, Moon RT.Cell biology. Making a point with Wnt signals[J]. Science,2013,339(6126):1388-1389. [9] Farin HF, van Es JH, Clevers H. Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells[J]. Gastroenterology,2012,143(6):1518-1529. [10] Qi Z, Li Y, Zhao B, et al.Bmp restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes[J]. Nat Commun,2017,8:13824. [11] Haramis AP, Begthel H, van den Born M, et al. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine[J]. Science,2004,303(5664):1684-1686. [12] Cammareri P, Rose AM, Vincent DF, et al.Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma[J]. Nat Commun,2016,7:12493. [13] Wiener Z, Band AM, Kallio P, et al.Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β[J]. Proc Natl Acad Sci U S A,2014,111(21):E2229-E2236. [14] Carulli AJ, Keeley TM, Demitrack ES, et al.Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration[J]. Dev Biol,2015,402(1):98-108. [15] Dignass AU, Sturm A.Peptide growth factors in the intestine[J]. Eur J Gastroenterol Hepatol,2001,13(7):763-770. [16] Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer[J]. Nature,2012,487(7407):330-337. [17] Barker N, Ridgway RA, van Es JH, et al. Crypt stem cells as the cells-of-origin of intestinal cancer[J]. Nature,2009,457(7229):608-611. [18] Schwitalla S, Fingerle AA, Cammareri P, et al.Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties[J]. Cell,2013,152(1-2):25-38. [19] Barker N, Clevers H.Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells[J]. Gastroenterology,2010,138(5):1681-1696. [20] Snyder JC, Rochelle LK, Lyerly HK, et al.Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network[J]. J Biol Chem,2013,288(15):10286-10297. [21] de Lau W, Barker N, Low TY, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling[J]. Nature,2011,476(7360):293-297. [22] Chen PH, Chen X, Lin Z, et al.The structural basis of R-spondin recognition by LGR5 and RNF43[J]. Genes Dev,2013,27(12):1345-1350. [23] Zebisch M, Xu Y, Krastev C, et al.Structural and mole-cular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin[J]. Nat Commun,2013,4:2787. [24] de Lau W, Peng WC, Gros P, et al. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength[J]. Genes Dev,2014,28(4):305-316. [25] Wakefield LM, Roberts AB.TGF-beta signaling: positive and negative effects on tumorigenesis[J]. Curr Opin Genet Dev,2002,12(1):22-29. [26] Massague J.TGFbeta in cancer[J]. Cell,2008,134(2):215-230. [27] Simms NA, Rajput A, Sharratt EA, et al.Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells[J]. BMC Cancer,2012,12:221. [28] Liu XQ, Rajput A, Geng L, et al.Restoration of transforming growth factor-beta receptor Ⅱ expression in colon cancer cells with microsatellite instability increases metastatic potential [29] van Meeteren LA, Goumans MJ, ten Dijke P. TGF-β receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy[J]. Curr Pharm Biotechnol,2011,12(12):2108-2120. [30] Cools N, van Tendeloo VF, Smits EL, et al. Immunosuppression induced by immature dendritic cells is mediated by TGF-beta/IL-10 double-positive CD4+ regulatory T cells[J]. J Cell Mol Med,2008,12(2):690-700. [31] Zhou X, Geng L, Wang D, et al.R-Spondin1/LGR5 activates TGFβ signaling and suppresses colon cancer metastasis[J]. Cancer Res,2017,77(23):6589-6602. [32] Evans GS, Flint N, Somers AS, et al.The development of a method for the preparation of rat intestinal epithelial cell primary cultures[J]. J Cell Sci,1992,101(Pt 1):219-231. [33] Sato T, Vries RG, Snippert HJ, et al.Single Lgr5 stem cells build crypt-villus structures in vitro without a me-senchymal niche[J]. Nature, 2009,459(7244):262-265. [34] Grabinger T, Luks L, Kostadinova F, et al.Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy[J]. Cell Death Dis,2014,5:e1228. [35] Schwank G, Koo BK, Sasselli V, et al.Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients[J]. Cell Stem Cell,2013,13(6):653-658. [36] Fumagalli A, Drost J, Suijkerbuijk SJ, et al.Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids[J]. Proc Natl Acad Sci U S A,2017,114(12):E2357-E2364. [37] Papapetrou EP.Patient-derived induced pluripotent stem cells in cancer research and precision oncology[J]. Nat Med,2016,22(12):1392-1401. [38] Usui T, Sakurai M, Enjoji S, et al.Establishment of a novel model for anticancer drug resistance in three-dimensional primary culture of tumor microenvironment[J]. Stem Cells Int,2016,2016:7053872. |
| [1] | 史曼曼, 王语欣, 马毓华, 王朝晖.系统性红斑狼疮的遗传学研究进展[J]. 内科理论与实践, 2022, 17(03): 267-272. |
| [2] | 雷晓旭 王春 赵曦.炎症微环境作用下ＢＭＰｓ－ＥＲＫ５信号通路对牙周膜干细胞成骨分化的影响#br#[J]. 组织工程与重建外科杂志, 2021, 17(1): 30-. |
| [3] | 康建强, 董杨阳, 杨玲, 宋珍, 范嘉盈.下呼吸道流感嗜血杆菌定植对哮喘小鼠气道炎症的影响及信号通路的研究[J]. 诊断学理论与实践, 2020, 19(1): 44-49. |
| [4] | 徐媛，郭遥，袁斯明，王慜，陈海妮，沈卫民.PPAR-gamma信号通路对Hem-MSCs体外成脂分化的影响[J]. 组织工程与重建外科杂志, 2019, 15(1): 1-9. |
| [5] | 陈海燕, 杨小宝, 许大康.新生物标志物在胃肠道肿瘤中疗效预测和预后价值的研究进展[J]. 诊断学理论与实践, 2019, 18(06): 704-710. |
| [6] | 白珊珊，韦敏.Carpenter综合征的分子遗传学研究进展[J]. 组织工程与重建外科杂志, 2017, 13(3): 169-171. |
| [7] | 王晓松, 汪明, 曹晖,.Hedgehog信号通路在消化道癌中的研究进展[J]. 外科理论与实践, 2017, 22(06): 546-549. |
| [8] | 孟玲宁, 刘锦燕, 李文静, 赵悦, 项明洁.抗真菌药物新作用靶点机制的研究进展[J]. 诊断学理论与实践, 2017, 16(05): 540-543. |
| [9] | 王敏, 张威浩,.滤泡上皮来源甲状腺癌基因改变及相关信号通路的研究进展[J]. 外科理论与实践, 2017, 22(03): 270-274. |
| [10] | 贺靖, 周明霞, 邹强,.甲状腺癌肿瘤干细胞及其分子调控机制的研究进展[J]. 外科理论与实践, 2017, 22(02): 178-182. |
| [11] | 陈军宝，肖苒，曹谊林.miRNA在间充质干细胞成骨分化过程中的作用[J]. 组织工程与重建外科杂志, 2016, 12(6): 375-377. |
| [12] | 杜磊, 徐俊, 罗天航,.Slit2/Robo4信号通路,内皮祖细胞与多器官功能障碍综合征的研究进展[J]. 外科理论与实践, 2016, 21(01): 87-90. |
| [13] | 陈云扬, 王维杰, 王化恺, 施敏敏, 张明钧, 杨卫平, 李宏为, 严佶祺,.雷帕霉素抑制门静脉高压症大鼠肠系膜血管新生[J]. 外科理论与实践, 2016, 21(01): 49-54. |
| [14] | 王宏伟, 姜翀弋, 王巍,.胰腺癌发生过程中信号通路的研究进展[J]. 外科理论与实践, 2015, 20(06): 530-534. |
| [15] | 陈云扬, 王维杰, 王化恺, 施敏敏, 张明钧, 严佶祺, 杨卫平, 彭承宏, 李宏为,.mTOR信号通路活化促进门静脉高压大鼠肠系膜血管新生的实验研究[J]. 外科理论与实践, 2015, 20(03): 221-225. |
| 阅读次数 | ||||||
| 全文 |
|
|||||
| 摘要 |
|
|||||
