Research progress of polydatin in treatment of digestive system diseases

Abstract

Abstract:

Polydatin is the main active ingredient extracted from the traditional Chinese herbal medicinePolygonum cuspidatum, which has multiple pharmacological effects such as anti-inflammation, antioxidant and apoptosis regulation. Its application in the treatment of liver disease, inflammatory bowel disease and other digestive system diseases has gradually attracted attention. This article reviews therapeutic progress of polydatin in benign and malignant diseases of the digestive system (liver, gallbladder, pancreas and gastrointestinal tract), analyzes the potential mechanism of polydatin in the treatment of digestive disorders. We hope to provide new ideas for in-depth research on application of polydatin in digestive disorders.

Key words:Polydatin,Digestive system,Polygonum cuspidatum

CLC Number:

R57
R256.3

WU Chao, ZHUANG Lei, MA Junjun, HE Zirui, SUN Yongshun. Research progress of polydatin in treatment of digestive system diseases[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(01): 76-80.

References50

[1]	梁春晓, 王珊珊, 陈淑静, 等. 虎杖化学成分及药理活性研究进展[J].中草药,2022,53(4):1264-1276.
[2]	林思, 秦慧真, 邓玲玉, 等. 虎杖苷药理作用及机制研究进展[J].中国实验方剂学杂志,2021,27(22):241-250.
[3]	Daina A, Michielin O, Zoete V. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules[J].Sci Rep,2017,7:42717.
[4]	Xiong G, Wu Z, Yi J, et al. ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties[J].Nucleic Acids Res,2021,49(W1):W5-W14.
[5]	Zhao G, Yang L, Zhong W, et al. Polydatin, a glycoside of resveratrol, is better than resveratrol in alleviating non-alcoholic fatty liver disease in mice fed a high-fructose diet[J].Front Nutr,2022,9:857879.
[6]	Oliviero F, Zamudio-Cuevas Y, Belluzzi E, et al. Polydatin and resveratrol inhibit the inflammatory process induced by urate and pyrophosphate crystals in THP-1 cells[J].Foods,2019,8(11):560.
[7]	Karami A, Fakhri S, Kooshki L, et al. Polydatin: pharmacological mechanisms, therapeutic targets, biological activities, and health benefits[J].Molecules,2022,27(19):6474.
[8]	何峰, 覃岭, 温祥臣. 虎杖苷对幽门螺旋杆菌脂多糖诱导的胃黏膜损伤大鼠胃黏膜细胞凋亡及TNF-α 水平影响[J].环球中医药,2018,11(9):1347-1351.
[9]	杨惠玲, 武继军, 史建伟. 虎杖苷对烫伤大鼠胃肠黏膜的保护作用[J].亚太传统医药,2008,4(7):23-25.
[10]	郑舜华. 中药胃黏膜保护的研究进展[J].中华消化杂志,2007,27(11):758-759.
[11]	Chen G, Yang Z, Wen D, et al. Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis[J].Immun Inflamm Dis,2021,9(3):959-970.
[12]	Lv T, Shen L, Yang L, et al. Polydatin ameliorates dextran sulfate sodium-induced colitis by decreasing oxidative stress and apoptosis partially via sonic hedgehog signaling pathway[J].Int Immunopharmacol,2018,64:256-263.
[13]	Liu B, Li S, Sui X, et al. Root extract ofPolygonum cuspidatum Siebold & Zucc.Ameliorates DSS-induced ulcerative colitis by affecting NF-kappaB signaling pathway in a mouse model via synergistic effects of polydatin, resveratrol, and emodin[J].Front Pharmacol,2018,9:347.
[14]	Peritore AF, D’Amico R, Cordaro M, et al. PEA/Polydatin: anti-inflammatory and antioxidant approach to counteract DNBS-induced colitis[J].Antioxidants (Basel),2021,10(3):464.
[15]	Liu YJ, Xu WH, Fan LM, et al. Polydatin alleviates DSS- and TNBS-induced colitis by suppressing Th17 cell differentiation via directly inhibiting STAT3[J].Phytother Res,2022,36(9):3662-3671.
[16]	Ebrahim HA, Elsherbini DMA. Renovation of intestinal barrier by polydatin in experimentally induced ulcerative colitis: comparative ultrastructural study with l-carnosine[J].Cells Tissues Organs,2021,210(4):275-292.
[17]	Yousef AI, Shawki HH, El-Shahawy AA, et al. Polydatin mitigates pancreatic β-cell damage through its antioxidant activity[J].Biomed Pharmacother,2021,133:111027.
[18]	于晓鹏.超高效液相色谱-质谱法对结石患者胆汁的代谢组学鉴定结果探讨与虎杖苷对胆固醇结石形成的影响和机制研究[D]. 沈阳: 中国医科大学,2023.
[19]	Chen X, Chan H, Zhang L, et al. The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux[J].J Cell Mol Med,2019,23(6):4290-4300. doi:10.1111/jcmm.14320pmid:30973211
[20]	Lai Y, Zhou C, Huang P, et al. Polydatin alleviated alcoholic liver injury in zebrafish larvae through ameliorating lipid metabolism and oxidative stress[J].J Pharmacol Sci,2018,138(1):46-53. doi:S1347-8613(18)30156-7pmid:30245287
[21]	Liu YH, Huang QH, Wu X, et al. Polydatin protects against acetaminophen-induced hepatotoxicity in mice via anti-oxidative and anti-apoptotic activities[J].Food Funct,2018,9(11):5891-5902.
[22]	Liu C, Wang W, Zhang K, et ak. Protective effects of polydatin from grapes andReynoutria japonicahoutt. on damaged macrophages treated with acetaminophen[J].Nutrients,2022,14(10):2077.
[23]	Cheng K, Niu J, Zheng X, et al. Aflatoxin-B1-exposure-induced hepatic injury could be alleviated by polydatin through reducing oxidative stress, inhibiting inflammation and improving mitophagy[J].Toxics,2023,11(4):309.
[24]	Tang D, Zhang Q, Duan H, et al. Polydatin: a critical promising natural agent for liver protection via antioxidative stress[J].Oxid Med Cell Longev,2022,2022:9218738.
[25]	Yan C, Hu W, Tu J, et al. Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease[J].J Transl Med,2023,21(1):300. doi:10.1186/s12967-023-04166-8pmid:37143126
[26]	Wong VW, Ekstedt M, Wong GL, et al. Changing epidemiology, global trends and implications for outcomes of NAFLD[J].J Hepatol,2023,79(3):842-852. doi:10.1016/j.jhep.2023.04.036pmid:37169151
[27]	He J, Qian YC, Yin YC, et al. Polydatin: a potential NAFLD therapeutic drug that regulates mitochondrial autophagy through SIRT3-FOXO3-BNIP3 and PINK1-PRKN mechanisms - a network pharmacology and experimental investigation[J].Chem Biol Interact,2024,398:111110.
[28]	Li R, Li J, Huang Y, et al. Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice[J].Int J Biol Sci,2018,14(11):1411-1425.
[29]	Koneru M, Sahu BD, Gudem S, et al. Polydatin alleviates alcohol-induced acute liver injury in mice: relevance of matrix metalloproteinases (MMPs) and hepatic antioxidants[J].Phytomedicine,2017,27:23-32.
[30]	Chen Y, Li Y, Jia P, et al. Polydatin attenuates intra-uterine growth retardation-induced liver injury and mitochondrial dysfunction in weanling piglets by improving energy metabolism and redox balance[J].Antioxidants (Basel),2022,11(4):666.
[31]	Lin L, Gong H, Li R, et al. Nanodrug with ROS and pH dual-sensitivity ameliorates liver fibrosis via multicellular regulation[J].Adv Sci (Weinh),2020,7(7):1903138.
[32]	Lan T, Zhuang L, Li S, et al. Polydatin attenuates hepatic stellate cell proliferation and liver fibrosis by suppressing sphingosine kinase 1[J].Biomed Pharmacother,2020,130:110586.
[33]	Zhao X, Yang Y, Yu H, et al. Polydatin inhibits ZEB1-invoked epithelial-mesenchymal transition in fructose-induced liver fibrosis[J].J Cell Mol Med,2020,24(22):13208-13222. doi:10.1111/jcmm.15933pmid:33058500
[34]	Bao HL, Chen CZ, Ren CZ, et al. Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization[J].Hepatobiliary Pancreat Dis Int,2024,23(1):25-34.
[35]	Chen Q, Shu C, Laurence AD, et al. Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial[J].Gut,2018,67(11):2006-2016. doi:10.1136/gutjnl-2018-315983pmid:29802174
[36]	Cabibbo G, Celsa C, Rimassa L, et al. Navigating the landscape of liver cancer management: study designs in clinical trials and clinical practice[J].J Hepatol,2024,80(6):957-966.
[37]	Jiao Y, Wu Y, Du D. Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma[J].Braz J Med Biol Res,2018,51(4):e6867.
[38]	Jiang J, Chen Y, Dong T, et al. Polydatin inhibits hepatocellular carcinoma via the AKT/STAT3-FOXO1 signaling pathway[J].Oncol Lett,2019,17(5):4505-4513. doi:10.3892/ol.2019.10123pmid:30944640
[39]	Farooq U, Wang H, Hu J, et al. Polydatin inhibits hepatocellular carcinoma cell proliferation and sensitizes doxorubicin and cisplatin through targeting cell mitotic machinery[J].Cells,2023,12(2):222.
[40]	Eng C, Yoshino T, Ruíz-García E, et al. Colorectal cancer[J].Lancet,2024,404(10449):294-310.
[41]	De Maria S, Scognamiglio I, Lombardi A, et al. Polydatin, a natural precursor of resveratrol, induces cell cycle arrest and differentiation of human colorectal Caco-2 cell[J].J Transl Med,2013,11:264.
[42]	Jin Y, Zhan X, Zhang B, et al. Polydatin exerts an antitumor effect through regulating the miR-382/PD-L1 axis in colorectal cancer[J].Cancer Biother Radiopharm,2020,35(2):83-91.
[43]	Zhou S, Sun Y, Wang K, et al. Polyvinylpyrrolidone-polydatin nanoparticles protect against oxaliplatin induced intestinal toxicityin vitroandin vivo[J].Food Chem Toxicol,2024,184:114427.
[44]	Bae H, Lee W, Song J, et al. Polydatin counteracts 5-fluorouracil resistance by enhancing apoptosis via calcium influx in colon cancer[J].Antioxidants (Basel),2021,10(9):1477.
[45]	Chen Q, Zeng YN, Zhang K, et al. Polydatin increases radiosensitivity by inducing apoptosis of stem cells in colorectal cancer[J].Int J Biol Sci,2019,15(2):430-440. doi:10.7150/ijbs.27050pmid:30745832
[46]	De Gregorio A, Krasnowska EK, Zonfrillo M, et al. Influence of polydatin on the tumor microenvironment in vitro: studies with a colon cancer cell model[J].Int J Mol Sci,2022,23(15):8442.
[47]	张翠翠, 李强. 虎杖苷通过蛋白激酶B信号通路影响胃癌细胞增殖凋亡[J].安徽医药,2021,25(9):1708-1712.
[48]	肖永琴, 张珂, 曹静平. 虎杖苷通过抑制miR-301a促进胃癌SGC-7901细胞凋亡的机制研究[J].中医药导报,2021,27(6):63-67.
[49]	祝金华, 赵士梅, 马秀岩, 等. 虎杖苷调节Akt/MDM2/p53信号通路对胆囊癌细胞增殖、迁移和细胞周期的影响[J].河北医药,2024,46(6):835-839.
[50]	Liu K, Liu J, Xu A, et al. The role of polydatin in inhibiting oxidative stress through SIRT1 activation: a comprehensive review of molecular targets[J].J Ethnopharmacol,2024,331:118322.