Renal thrombotic microangiopathy associated with chemotherapy: two case reports

Abstract

Abstract:

Patient 1 was a 68-year-old male who had been diagnosed with a malignant lung tumor for three years. This case developed proteinuria during bevacizumab treatment and had normal renal function. Patient 2 was a 70-year-old male diagnosed with gastric adenocarcinoma for two years, this case developed proteinuria after three months chemotherapy with oxaliplatin, leucovorin, and fluorouracil, but his renal function was normal. Renal biopsy of the two patients showed thrombotic microangiopathy. After treatment with sacubitril/valsartan sodium combined with dapagliflozin, proteinuria in two patients decreased, and their renal function was still stable.

Key words:Thrombotic microangiopathy,Antineoplastic agents,Renal involvement

CLC Number:

R692.2

WANG Yining, CHEN Nannan, CHENG Lin, LIU Zhenhua, ZHENG Xiaoyan, XU Jing, PAN Xiaoxia, CHEN Yongxi, CHEN Xiaonong. Renal thrombotic microangiopathy associated with chemotherapy: two case reports[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(04): 322-327.

Figures/Tables1

References40

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