The role and research progress of microRNA in acute leukemia

Abstract

CLC Number:

R733.7

HUANG Rong, LIU Jing’an, ZHU Yilin, SHI Xiaofeng. The role and research progress of microRNA in acute leukemia[J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(06): 451-456.

Figures/Tables2

miRNA类型	作用结果	作用方式	作用靶基因	疾病类型	调控的细胞类型	信号通路	参考文献
9	抑癌	下调	CXCR4	AML	Kasumi-1		[ 8 ]
9	抑癌	下调		AML	HL-60	Hippo/YAP	[ 9 ]
93	促癌	上调	DAB2	AML	THP-1	PI3K/AKT	[ 10 ]
139-5p	抑癌	下调	TSPAN3	AML	HL-60、OCI-AML3	PI3K/AKT	[ 11 ]
139-5p	抑癌	下调	MNT	APL	NB4		[ 12 ]
20a-5p	抑癌	下调	PPP6C	AML	THP-1、U937		[ 13 ]
451	抑癌	下调	HMGB1	AML	HL-60、THP-1		[ 14 ]
29b-3p	抑癌	下调	HUR/ELAVL1	AML	K562、U937	NF-κB和JAK/STAT	[ 15 ]
504-3p	抑癌	下调	MTHFD2	AML	HL-60、THP-1		[ 16 ]
4792	抑癌	下调	KINDLIN3	AML	HL-60、Kg1a		[ 17 ]
204	抑癌	下调	HGF	AML	Kasumi-1、HL-60	HGF/c-Met	[ 18 ]
182-5p	促癌	上调	BCL2L12	AML	AML5、Kasumi-1		[ 19 ]
362-5p	促癌	上调	GAS7	AML	THP-1、HL-60		[ 20 ]
10b	促癌	上调	HOXD10	AML	HL-60		[ 21 ]
582-3p	抑癌	下调	CCNB2	AML	THP-1		[ 22 ]
335-3p	抑癌	下调	EIF3E	AML	THP-1、U937		[ 23 ]
1306-5p	促癌	上调	PHF6	AML	HL-60、K562		[ 24 ]
148a-3p	抑癌	下调	CDK6	AML	J111、KG-1a		[ 25 ]
1271-5p	抑癌	下调	ZIC2	AML	AML193、OCI-AML2		[ 26 ]
550-1	抑癌	下调	WWTR1	AML	MV4-11、Kasumi-1		[ 27 ]
155	促癌	上调	ZNF238	ALL	CEM-C1、Jurkat、MOLT-3、MOLT-4		[ 28 ]
342	抑癌	下调	Naa10p	AML	Kg1a、HL60		[ 29 ]
223	抑癌	下调	FOXO1	ALL	CCRF-CEM、NALM-6		[ 30 ]

miRNA类型	对药物敏感性的影响	影响的药物	疾病类型	调控的细胞类型	调控的靶基因	信号通路	参考文献
9	过表达后增强	柔红霉素	AML	THP-1、KG-1、 HL60、Kasumi-1	EIF5A2	EIF5A2/MCL-1	[ 45 ]
33b	过表达后增强	柔红霉素	AML	THP-1、KG-1、 Kasumi-1、HL-60	EIF5A2	EIF5A2/MCL-1	[ 46 ]
15a-5p	过表达后抑制	柔红霉素	AML	K562	ATG9A、ATG14、 GABARAPL1、SMPD1		[ 47 ]
15a-5p、21-5p	过表达后抑制	阿糖胞甘、柔红霉素	AML	K562、OCI-AML3	PDCD4、ARL2、BTG2		[ 48 ]
199a-5p	过表达后增强	多柔比星	AML	K562	DRAM1	DRAM1/自噬轴	[ 49 ]
146a、155、181a	沉默后增强	泼尼松龙	ALL	SUP-B15			[ 42 ]
130a	沉默后增强	多柔比星	AML	HL-60			[ 50 ]
let-7f	过表达后增强	多柔比星	AML	K562、K562/A02	ABCC5、ABCC10		[ 51 ]
145	过表达后增强	地塞米松	ALL	CEM-C1			[ 52 ]

References53

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The role and research progress of microRNA in acute leukemia

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