Effect of selenium yeast combined with vitamin D on thyroid-associated antibody levels in patients with Hashimoto thyroiditis at different ages

Abstract

Abstract:

ObjectiveTo investigate the effect of selenium yeast combined with vitamin D on thyroid related antibody levels in Hashimoto thyroiditis (HT) patients at different ages.MethodIn this study, 148 patients with HT (96 adults and 52 minors) were selected from December 2017 to December 2019. The patients were divided into control group and observation group. The patients in the control group were treated with routine methods and the observation group of patients used selenium yeast and vitamin D besides routine treatment. After 6 months, the levels of thyroid peroxidase autoantibody (TPOAb) and thyroglobulin antibody (TgAb) before and after treatment were compared between two groups.ResultsSerum 25-hydroxyvitamin D₃[25(OH) D₃] levels were detected in both adults and minors before combined treatment. The average 25(OH) D₃level in 2 groups before treatment was lower than normal, while the 25(OH) D₃level in minors was higher than that in adults (P<0.05). There was no significant difference in TPOAb and TgAb in control group and the observation group before treatment(P>0.05). The levels of TPOAb and TgAb in the observation group were significantly lower than those in the control group(P<0.05), in addition, the treatment effect of the observation group was significantly higher than that of the control group(P<0.05).ConclusionsThe treatment of HT with selenium yeast combined with vitamin D on the basis of routine treatment can effectively reduce the TPOAb and TgAb level in adult and minor patients. The therapeutic effect is remarkable and has application value in the clinic.

Key words:Selenium yeast,Vitamin D,Age stratification,Hashimoto thyroiditis,Thyroid peroxidase autoantibody,Thyroglobulin antibody

CLC Number:

R581.4

GU Wei, HOU Liping, LI Xiaolong, GENG Jianlin. Effect of selenium yeast combined with vitamin D on thyroid-associated antibody levels in patients with Hashimoto thyroiditis at different ages[J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(06): 392-396.

Figures/Tables5

组别	对照组	观察组
成年	n=47	n=45
治疗前	15.12±3.98	14.32±4.28
治疗后	16.39±2.99	31.61±5.12^2）
t	1.24	9.86
P	>0.05	<0.05
未成年	n=24	n=24
治疗前	22.28±5.21^1）	22.85±4.90^1）
治疗后	24.15±2.01	39.04±3.89^2）
t	0.98	8.23
P	>0.05	<0.05

项目	治疗前		治疗后
对照组（n=47）	观察组（n=45）	对照组（n=24）	观察组（n=24）	对照组（n=47）	观察组（n=45）	对照组（n=24）	观察组（n=24）
FT₃（pmol/L）	4.07±0.89	4.89±0.91	5.29±0.78	5.39±1.02	5.59±1.29	5.01±1.22	5.32±1.09	5.67±1.89
FT₄（pmol/L）	12.79±4.91	12.29±5.12	13.21±4.71	13.29±4.98	13.92±5.01	13.02±4.98	13.99±4.29	14.32±5.03
TSH（mU/L）	3.22±1.38	3.29±1.29	3.09±0.57	2.99±1.93	3.91±0.29	3.01±0.98	2.98±0.47	3.05±0.95

项目	对照组（n=47）	观察组（n=45）
TPOAb（U/mL）
治疗前	1 411±206	1 390±242^1）
治疗后6个月	1 391±194	684±259^2）
TgAb（U/mL）
治疗前	808±300	837±274^1）
治疗后6个月	789±276	403±188^2）
t^*	10.236	11.372
P^*	<0.05	<0.05

项目	对照组（n=24）	观察组（n=24）
TPOAb
治疗前	1 790±216	1 586±219^1）
治疗后6个月	1 469±197	706±230^2）
TgAb
治疗前	907±290	958±224^1）
治疗后6个月	899±266	489±200^2）
t^*	10.236	11.372
P^*	<0.05	<0.05

组别	显效	有效	无效	总有效率
成年
观察组（n=45）	13（28.9）	22（48.9）	10（22.2）	（77.8）
对照组（n=47）	5（10.6）	8（17.0）	32（72.3）	（27.7）
未成年
观察组（n=24）	8（33.3）	11（45.8）	6（20.8）	（79.2）
对照组（n=24）	3（12.5）	3（12.5）	18（75.0）	（25.0）

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