
内科理论与实践››2025,Vol. 20››Issue (01): 50-53.doi:10.16138/j.1673-6087.2025.01.10
孙倩1, 林诗雨2, 夏梦婕3, 周海燕3(
), 王秀薇4(
)
收稿日期:2024-07-08出版日期:2025-02-28发布日期:2025-04-30通讯作者:周海燕 E-mail:zhaiyan.com@163.com;王秀薇 E-mail:wxw231888@126.comSUN Qian1, LIN Shiyu2, XIA Mengjie3, ZHOU Haiyan3(
), WANG Xiuwei4(
)
Received:2024-07-08Online:2025-02-28Published:2025-04-30摘要:
疼痛作为帕金森病最常见的非运动症状之一,其发病机制复杂,临床分类多样。目前西医治疗以多巴胺能替代疗法为主,但仅能缓解部分疼痛症状,且长期治疗存在不可避免的运动并发症和药物不良反应,疗效存在明显局限性。中医在疼痛治疗领域具独特优势。本文总结近年中西医治疗帕金森病疼痛的相关文献,旨在为中西医结合治疗该病提供科学参考及治疗思路。
中图分类号:
孙倩, 林诗雨, 夏梦婕, 周海燕, 王秀薇. 帕金森病疼痛的中西医治疗研究进展[J]. 内科理论与实践, 2025, 20(01): 50-53.
SUN Qian, LIN Shiyu, XIA Mengjie, ZHOU Haiyan, WANG Xiuwei. Research progress on treatment of Parkinson disease-related pain with traditional Chinese and Western medicine[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(01): 50-53.
| [1] | Silverdale MA, Kobylecki C, Kass-lliyya L, et al. A detailed clinical study of pain in 1957 participants with early/moderate Parkinson’s disease[J].Parkinsonism Relat Disord,2018,56:27-32. |
| [2] | Mylius V, Perez Lloret S, Cury RG, et al. The Parkinson disease pain classification system: results from an international mechanism-based classification approach[J].Pain,2021,162(4):1201-1210. |
| [3] | Raja SN, Carr DB, Cohen M, et al. The revised international association for the study of pain definition of pain: concepts, challenges, and compromises[J].Pain,2020,161(9):1976-1982. |
| [4] | Allen NE, Romaliiska O, Naisby J. Pain and the non-pharmacological management of pain in people with Parkinson’s disease[J].J Parkinsons Dis,2024,14(s1):S65-S80. |
| [5] | Broetz D, Eichner M, Gasser T, et al. Radicular and nonradicular back pain in Parkinson’s disease: a controlled study[J].Mov Disord,2007,22(6):853-856. |
| [6] | Kosek E, Cohen M, Baron R, et al. Do we need a third mechanistic descriptor for chronic pain states?[J]Pain,2016,157(7):1382-1386. doi:10.1097/j.pain.0000000000000507pmid:26835783 |
| [7] | Fitzcharles MA, Cohen SP, Clauw DJ, et al. Nociplastic pain: towards an understanding of prevalent pain conditions[J].Lancet,2021,397(10289):2098-2110. doi:10.1016/S0140-6736(21)00392-5pmid:34062144 |
| [8] | Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances[J].Lancet,2021,397(10289):2082-2097. doi:10.1016/S0140-6736(21)00393-7pmid:34062143 |
| [9] | Poewe WH, Lees AJ, Stern GM. Dystonia in Parkinson’s disease: clinical and pharmacological features[J].Ann Neurol,1988,23(1):73-78. doi:10.1002/ana.410230112pmid:3345068 |
| [10] | Battista AF, Wolff BB. Levodopa and induced-pain response[J].Arch Intern Med,1973,132(1):70-74. pmid:4716428 |
| [11] | Brefel-Courbon C, Payoux P, Thalamas C, et al. Effect of levodopa on pain threshold in Parkinson’s disease: a clinical and positron emission tomography study[J].Mov Disord,2005,20(12):1557-1563. |
| [12] | Gerdelat-Mas A, Simonetta-Moreau M, Thalamas C, et al. Levodopa raises objective pain threshold in Parkinson’s disease: a RⅢreflex study[J].J Neurol Neurosurg Psychiatry,2007,78(10):1140-1142. doi:10.1136/jnnp.2007.120212pmid:17504881 |
| [13] | Rascol O, Zesiewicz T, Chaudhuri KR, et al. A randomized controlled exploratory pilot study to evaluate the effect of rotigotine transdermal patch on Parkinson’s disease-associated chronic pain[J].J Clin Pharmacol,2016,56(7):852-861. |
| [14] | Raeder V, Boura I, Leta V, et al. Rotigotine transdermal patch for motor and non-motor Parkinson’s disease: a review of 12 years’ clinical experience[J].CNS Drugs,2021,35(2):215-231. |
| [15] | Hattori N, Tsuboi Y, Yamamoto A, et al. Efficacy and safety of safinamide as an add-on therapy to L-DOPA for patients with Parkinson’s disease: a randomized, double-blind, placebo-controlled, phaseⅡ /Ⅲ study[J].Parkinsonism Relat Disord,2020,75:17-23. |
| [16] | Kurihara K, Mishima T, Fujioka S, Tsuboi Y. Efficacy and safety evaluation of safinamide as an add-on treatment to levodopa for parkinson’s disease[J].Expert Opin Drug Saf,2022,21(2):137-147. |
| [17] | Chaudhuri KR, Odin P, Ferreira JJ, et al. Opicapone versus placebo in the treatment of Parkinson’s disease patients with end-of-dose motor fluctuation-associated pain: rationale and design of the randomised, double-blind OCEAN (opicapone effect on motor fluctuations and pain) trial[J].BMC Neurol,2022,22(1):88. |
| [18] | Qureshi AR, Rana AQ, Malik SH, et al. Comprehensive examination of therapies for pain in Parkinson’s disease: a systematic review and meta-analysis[J].Neuroepidemiology,2018,51(3-4):190-206. doi:10.1159/000492221pmid:30153669 |
| [19] | Djaldetti R, Yust-Katz S, Kolianov V, et al. The effect of duloxetine on primary pain symptoms in Parkinson disease[J].Clin Neuropharmacol,2007,30(4):201-205. doi:10.1097/wnf.0b013e3180340319pmid:17762316 |
| [20] | Sidhu HS, Sadhotra A. Current status of the new antiepileptic drugs in chronic pain[J].Front Pharmacol,2016,7:276. |
| [21] | Ford B. Pain in Parkinson’s disease[J].Mov Disord,2010,25 Suppl1:S98-S103. |
| [22] | Argoff CE. New analgesics for neuropathic pain: the lidocaine patch[J].Clin J Pain,2000,16(2 Suppl):S62-S66. |
| [23] | Viseux FJF, Delval A, Simoneau M, Defebvre L. Pain and Parkinson’s disease: current mechanism and management updates[J].Eur J Pain,2023,27(5):553-567. |
| [24] | 上海中西医结合学会慢性神经系统疾病专业委员会. 帕金森病运动处方专家共识[J].同济大学学报(医学版),2021,42(6):729-735. |
| [25] | 武琪, 刘志坚, 程玲, 等. 水疗法对轻中度帕金森患者作用效果的荟萃分析[J].临床与病理杂志,2021,41(2):374-382. |
| [26] | Yang QH, Zhang YH, Du SH, et al. Non-invasive brain stimulation for central neuropathic pain[J].Front Mol Neurosci,2022,15:879909. |
| [27] | Flouty O, Yamamoto K, Germann J, et al. Idiopathic Parkinson’s disease and chronic pain in the era of deep brain stimulation: a systematic review and meta-analysis[J].J Neurosurg,2022,137(6):1821-1830. |
| [28] | Zimmers S, Robieux L, Bungener C. Towards a better comprehension and management of pain and psychological distress in Parkinson’s: the role of catastrophizing[J].J Geriatr Psychiatry Neurol,2023,36(5):351-365. |
| [29] | Pickut B, Vanneste S, Hirsch MA, et al. Mindfulness training among individuals with Parkinson’s disease: Neurobehavioral Effects[J].Parkinsons Dis,2015,2015:816404. |
| [30] | 汪海芹, 蔡忠明. 大定风珠治疗帕金森病40例临床观察[J].世界最新医学信息文摘(连续型电子期刊),2019,19(26):155. |
| [31] | 侯宇, 马效麟, 张婷, 等. 补肾养肝息风汤对肝肾阴虚型帕金森病患者综合功能的影响[J].湖北中医药大学学报,2021,23(3):66-68. |
| [32] | 戈盾. 止颤汤合芍药甘草汤治疗帕金森病疼痛的临床疗效观察[J].内蒙古中医药,2017,36(14):44-45. |
| [33] | 郑春叶, 吕少华, 黄强, 等. 加味桂枝加葛根汤治疗帕金森病疼痛40例临床观察[J].中国民间疗法,2018,26(11):37-38. |
| [34] | 张秀琳, 惠振, 王苏雷, 等. 加减地黄饮子治疗帕金森病疼痛临床研究[J].陕西中医,2021,42(5):620-624. |
| [35] | 王秀薇. 胡建华平肝熄风通络法治疗神经系统疾病[J].上海中医药杂志,2006(12):9-10. |
| [36] | Feng Z, Cui S, Yang H, et al. Acupuncture for neuropathic pain: A meta-analysis of randomized control trials[J].Front Neurol,2023,13:1076993. |
| [37] | Lee SH, Lim S. Clinical effectiveness of acupuncture on Parkinson disease: a PRISMA-compliant systematic review and meta-analysis[J].Medicine (Baltimore),2017,96(3):e5836. |
| [38] | Yu SW, Lin SH, Tsai CC, et al. Acupuncture effect and mechanism for treating pain in patients with Parkinson’s disease[J].Front Neurol,2019,10:1114. |
| [39] | Shaosong W, Jingqing S, Qingyin F, et al. Effectivenss of electroacupuncture for skeletal muscle pain in Parkinson’s disease: a clinical randomized controlled trial[J].J Tradit Chin Med,2024,44(2):388-395. doi:10.19852/j.cnki.jtcm.20240203.004 |
| [40] | 于楠楠, 马琳, 毕海洋, 等. 浮针治疗帕金森病伴发四肢疼痛临床研究[J].针灸临床杂志,2020,36(1):37-40. |
| [41] | Fusaro M, Bufacchi RJ, Nicolardi V, et al. The analgesic power of pleasant touch in individuals with chronic pain: recent findings and new insights[J].Front Integr Neurosci,2022,16:956510. |
| [42] | Buhmann C, Wrobel N, Grashorn W, et al. Pain in Parkinson disease: a cross-sectional survey of its prevalence, specifics, and therapy[J].J Neurol,2017,264(4):758-769. doi:10.1007/s00415-017-8426-ypmid:28243753 |
| [43] | Deuel LM, Seeberger LC. Complementary therapies in parkinson disease: a review of acupuncture, tai chi, qi gong, yoga, and cannabis[J].Neurotherapeutics,2020,17(4):1434-1455. |
| [44] | 蔡鸣春, 顾炜萍, 王厹东, 等. 中药热熨护理对帕金森病伴发肌肉骨骼性疼痛的影响研究[J].现代中西医结合杂志,2022,31(14):2009-2011. |
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