帕金森病冻结步态的相关因素研究进展

摘要/Abstract

中图分类号:

R593.2

王新新, 田敏, 张秀芳, 刘艺鸣. 帕金森病冻结步态的相关因素研究进展[J]. 内科理论与实践, 2022, 17(04): 339-343.

图/表1

表1

PD患者冻结步态的相关因素研究现状

类型	名称	与PD伴FOG相关性
人口学因素	性别	FOG发生率男性>女性
	年龄/发病年龄	暂无定论
	教育水平	暂无定论
病程与分期	病程	病程越长,FOG发生率越高
	H&Y分期	分期越高,FOG发生率越高
运动症状	临床分型与起病部位	PIGD型、下肢起病者更易发生FOG
	异常步态/跌倒/平衡障碍	FOG发生率增加
	运动波动	FOG发生率增加
非运动症状	焦虑与抑郁	FOG发生率增加
	认知功能减退	FOG发生率增加
	睡眠	暂无定论
抗PD药物	左旋多巴	FOG发生率增加
	多巴胺受体激动剂	暂无定论

表1

参考文献46

[1]	Okuma Y, Silva de Lima AL, Fukae J, et al. A prospective study of falls in relation to freezing of gait and response fluctuations in Parkinson’s disease[J]. Parkinsonism Relat Disord, 2018, 46: 30-35. doi:10.1016/j.parkreldis.2017.10.013 URL
[2]	Walton CC, Shine JM, Hall JM, et al. The major impact of freezing of gait on quality of life in Parkinson’s disease[J]. J Neurol, 2015, 262(1):108-115. doi:10.1007/s00415-014-7524-3 URL
[3]	Giladi N, Nieuwboer A. Understanding and treating freezing of gait in Parkinsonism, proposed working definition, and setting the stage[J]. Mov Disord, 2008, 23 Suppl 2: S423-S425.
[4]	Schaafsma JD, Balash Y, Gurevich T, et al. Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson’s disease[J]. Eur J Neurol, 2003, 10(4): 391-398. pmid:12823491
[5]	Zhang WS, Gao C, Tan YY, et al. Prevalence of freezing of gait in Parkinson’s disease: a systematic review and meta-analysis[J]. J Neurol, 2021, 268(11): 4138-4150. doi:10.1007/s00415-021-10685-5 URL
[6]	Factor SA. The clinical spectrum of freezing of gait in atypical parkinsonism[J]. Mov Disord, 2008, 23 Suppl 2: S431-S438.
[7]	Nutt JG, Bloem BR, Giladi N, et al. Freezing of gait: moving forward on a mysterious clinical phenomenon[J]. Lancet Neurol, 2011, 10(8): 734-744. doi:10.1016/S1474-4422(11)70143-0 URL
[8]	Cucca A, Biagioni MC, Fleisher JE, et al. Freezing of gait in Parkinson’s disease: from pathophysiology to emerging therapies[J]. Neurodegener Dis Manag, 2016, 6(5): 431-446. doi:10.2217/nmt-2016-0018 URL
[9]	Kostic VS, Agosta F, Pievani M, et al. Pattern of brain tissue loss associated with freezing of gait in Parkinson disease[J]. Neurology, 2012, 78(6): 409-416. doi:10.1212/WNL.0b013e318245d23cpmid:22282641
[10]	Calabresi P, Picconi B, Parnetti L, et al. A convergent model for cognitive dysfunctions in Parkinson’s disease: the critical dopamine-acetylcholine synaptic balance[J]. Lancet Neurol, 2006, 5(11): 974-983. pmid:17052664
[11]	Bartels AL, de Jong BM, Giladi N, et al. Striatal dopa and glucose metabolism in PD patients with freezing of gait[J]. Mov Disord, 2006, 21(9): 1326-1332. doi:10.1002/mds.20952 URL
[12]	Brooks VB, Stoney SD Jr. Motor mechanisms: the role of the pyramidal system in motor control[J]. Annu Rev Physiol, 1971, 33: 337-392. pmid:4951052
[13]	Plotnik M, Giladi N, Hausdorff JM. Is freezing of gait in Parkinson’s disease a result of multiple gait impairments? Implications for treatment[J]. Parkinsons Dis, 2012, 2012: 459321.
[14]	Lewis SJ, Barker RA. A pathophysiological model of freezing of gait in Parkinson’s disease[J]. Parkinsonism Relat Disord, 2009, 15(5): 333-338. doi:10.1016/j.parkreldis.2008.08.006 URL
[15]	Vandenbossche J, Deroost N, Soetens E, et al. Freezing of gait in Parkinson’s disease: disturbances in automaticity and control[J]. Front Hum Neurosci, 2013, 6: 356.
[16]	Jacobs JV, Nutt JG, Carlson-Kuhta P, et al. Knee trembling during freezing of gait represents multiple anticipatory postural adjustments[J]. Exp Neurol, 2009, 215(2): 334-341. doi:10.1016/j.expneurol.2008.10.019pmid:19061889
[17]	Macht M, Kaussner Y, Möller JC, et al. Predictors of freezing in Parkinson’s disease: a survey of 6,620 patients[J]. Mov Disord, 2007, 22(7): 953-956. doi:10.1002/mds.21458 URL
[18]	Kim R, Lee J, Kim HJ, et al. CSF β-amyloid42 and risk of freezing of gait in early Parkinson disease[J]. Neurology, 2019, 92(1): e40-e47.
[19]	Djaldetti R, Rigbi A, Greenbaum L, et al. Can early dopamine transporter imaging serve as a predictor of Parkinson’s disease progression and late motor complications?[J]. J Neurol Sci, 2018, 390: 255-260. doi:S0022-510X(18)30220-Xpmid:29801899
[20]	Shulman LM. Is there a connection between estrogen and Parkinson’s disease?[J]. Parkinsonism Relat Disord, 2002, 8(5): 289-295. doi:10.1016/S1353-8020(02)00014-7 URL
[21]	Ehgoetz Martens KA, Lukasik EL, Georgiades MJ, et al. Predicting the onset of freezing of gait: a longitudinal study[J]. Mov Disord, 2018, 33(1): 128-135. doi:10.1002/mds.27208 URL
[22]	Zhang H, Yin X, Ouyang Z, et al. A prospective study of freezing of gait with early Parkinson disease in Chinese patients[J]. Medicine (Baltimore), 2016, 95(26): e4056.
[23]	Ortelli P, Ferrazzoli D, Cian V, et al. How Cognition and motivation “freeze” the motor behavior in Parkinson’s disease[J]. Front Neurosci, 2019, 13: 1302. doi:10.3389/fnins.2019.01302 URL
[24]	Contreras A, Grandas F. Risk factors for freezing of gait in Parkinson’s disease[J]. J Neurol Sci, 2012, 320(1-2):66-71. doi:10.1016/j.jns.2012.06.018pmid:22795382
[25]	Perez-Lloret S, Negre-Pages L, Damier P, et al. Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease[J]. JAMA Neurol, 2014, 71(7): 884-890. doi:10.1001/jamaneurol.2014.753pmid:24839938
[26]	Ou R, Wei Q, Cao B, et al. Predictors of freezing of gait in Chinese patients with Parkinson’s disease[J]. Brain Behav, 2018, 8(3): e00931.
[27]	Herman T, Shema-Shiratzky S, Arie L, et al. Depressive symptoms may increase the risk of the future development of freezing of gait in patients with Parkinson’s disease: findings from a 5-year prospective study[J]. Parkinsonism Relat Disord, 2019, 60: 98-104. doi:10.1016/j.parkreldis.2018.09.013 URL
[28]	Banks SJ, Bayram E, Shan G, et al. Non-motor predictors of freezing of gait in Parkinson’s disease[J]. Gait Posture, 2019, 68: 311-316. doi:10.1016/j.gaitpost.2018.12.009 URL
[29]	Tan DM, McGinley JL, Danoudis ME, et al. Freezing of gait and activity limitations in people with Parkinson’s disease[J]. Arch Phys Med Rehabil, 2011, 92(7): 1159-1165. doi:10.1016/j.apmr.2011.02.003 URL
[30]	Ge HL, Chen XY, Lin YX, et al. The prevalence of freezing of gait in Parkinson’s disease and in patients with different disease durations and severities[J]. Chin Neurosurg J, 2020, 6: 17. doi:10.1186/s41016-020-00197-y URL
[31]	Kim R, Lee J, Kim HJ, et al. CSF β-amyloid 42 and risk of freezing of gait in early Parkinson disease[J]. Neurology, 2019, 92(1): e40-e47.
[32]	Kim R, Lee J, Kim Y, et al. Presynaptic striatal dopaminergic depletion predicts the later development of freezing of gait in de novo Parkinson’s disease[J]. Parkinsonism Relat Disord, 2018, 51: 49-54. doi:10.1016/j.parkreldis.2018.02.047 URL
[33]	Forsaa EB, Larsen JP, Wentzel-Larsen T, et al. A 12-year population-based study of freezing of gait in Parkinson’s disease[J]. Parkinsonism Relat Disord, 2015, 21(3): 254-258. doi:10.1016/j.parkreldis.2014.12.020 URL
[34]	Zhang F, Shi J, Duan Y, et al. Clinical features and related factors of freezing of gait in patients with Parkinson’s disease[J]. Brain Behav, 2021, 11(11): e2359.
[35]	Magrinelli F, Picelli A, Tocco P, et al. Pathophysiology of motor dysfunction in Parkinson’s disease as the rationale for drug treatment and rehabilitation[J]. Parkinsons Dis, 2016, 2016: 9832839.
[36]	Schlenstedt C, Muthuraman M, Witt K, et al. Postural control and freezing of gait in Parkinson’s disease[J]. Parkinsonism Relat Disord, 2016, 24: 107-112. doi:10.1016/j.parkreldis.2015.12.011 URL
[37]	Ou R, Guo X, Song W, et al. Freezing of gait in Chinese patients with Parkinson disease[J]. J Neurol Sci, 2014, 345(1-2): 56-60. doi:10.1016/j.jns.2014.07.002 URL
[38]	Amboni M, Cozzolino A, Longo K, et al. Freezing of gait and executive functions in patients with Parkinson’s disease[J]. Mov Disord, 2008, 23(3): 395-400. doi:10.1002/mds.21850 URL
[39]	Amboni M, Barone P, Picillo M, et al. A two-year follow-up study of executive dysfunctions in Parkinsonian patients with freezing of gait at on-state[J]. Mov Disord, 2010, 25(6): 800-802. doi:10.1002/mds.23033 URL
[40]	Nantel J, McDonald JC, Tan S, et al. Deficits in visuospatial processing contribute to quantitative measures of freezing of gait in Parkinson’s disease[J]. Neuroscience, 2012, 221: 151-156. doi:10.1016/j.neuroscience.2012.07.007pmid:22796080
[41]	Tang X, Yu L, Yang J, et al. Association of sleep disturbance and freezing of gait in Parkinson disease: prevention/delay implications[J]. J Clin Sleep Med, 2021, 17(4): 779-789. doi:10.5664/jcsm.9022 URL
[42]	Romenets SR, Gagnon JF, Latreille V, et al. Rapid eye movement sleep behavior disorder and subtypes of Parkinson’s disease[J]. Mov Disord, 2012 Jul, 27(8): 996-1003. doi:10.1002/mds.25086 URL
[43]	丁园, 祖洁, 董丽果, 等. 帕金森病冻结步态的临床特点及相关影响因素[J]. 临床神经病学杂志, 2019, 32(2): 118-121.
[44]	Alibiglou L, Videnovic A, Planetta PJ, et al. Subliminal gait initiation deficits in rapid eye movement sleep behavior disorder: a harbinger of freezing of gait?[J]. Mov Disord, 2016, 31(11): 1711-1719. doi:10.1002/mds.26665 URL
[45]	Benninger DH, Michel J, Waldvogel D, et al. REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson[J]. Mov Disord, 2010, 25(11): 1597-1604. doi:10.1002/mds.23121 URL
[46]	Giladi N, Treves TA, Simon ES, et al. Freezing of gait in patients with advanced Parkinson’s disease[J]. J Neural Transm (Vienna), 2001, 108(1): 53-61.

帕金森病冻结步态的相关因素研究进展

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