Association of metabolically healthy obesity, insulin resistance with risk of diabetes: a prospective study

Abstract

Abstract:Objective:To investigate the association between metabolically healthy obesity (MHO) and risk of diabetes in population in Shanghai and to assess the role of insulin resistance in their relationship.Methods:A prospective study was performed among 1 967 participants aged 40 years or older in Baoshan community, Shanghai. The participants were categorized into four groups according to obesity and metabolic status: metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese(MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Questionnaire interview, anthropometric measurements, and biochemical measurements were obtained in the participants. Metabolic profiles and rate of incident diabetes were compared between the groups.Results:After a median follow-up period of 4 years, the rate of incident diabetes in group MHNO, group MUNO, group MHO, and group MUO were 3.4%, 16.4%, 7.7%, and 17.5%, respectively. Multivariate logistic analysis revealed that patients in group MHO had an increased risk of incident diabetes [odds ratio (OR)=2.25, 95% confidence interval (CI) 1.31-3.85] when compared with subjects in MHNO. Compared with patients in group MHNO, patients resistant to insulin [homeostasis model assessment of insulin resistance(HOMA-IR≥2.5)] in group MHO had an increasedORfor incident diabetes (OR=5.20, 95%CI2.56-10.56).Conclusions:The 4-year follow-up revealed that patients of MHO have a high incidence of diabetes in which insulin resistance might play a role.

Key words:Obesity,Metabolic healthy,Diabetes,Insulin resistance

CLC Number:

R587.1

NI Hengru, LIN Lin, PENG Kui, HAO Mingli, WANG Tiange, GAO Jinli. Association of metabolically healthy obesity, insulin resistance with risk of diabetes: a prospective study[J]. Journal of Diagnostics Concepts & Practice, 2017, 16(04): 419-424.

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