Analysis on relationship between polymorphism of chromosome region 9p21 and susceptibility of carotid plaque in acute non-cardioembolic cerebral infarction patients

Abstract

Abstract:Objective:To analyze the relationship between gene polymorphism of chromosome region 9p21 (rs10757274, rs7044859, rs4977574 and rs496892) and carotid plaque in acute non-cardioembolic cerebral infarction patients.Methods:The gene polymorphisms of site rs10757274, rs7044859, rs4977574 and rs496892 in chromosome region 9p21 were analyzed with polymerase chain reaction-ligase detection reaction (PCR-LDR) in 411 acute non-cardioembolic cerebral infarction patients (230 with carotid plaque while 181 without).Results:Compared with those without carotid plaque, an increased frequency in the G allele of rs4977574 was seen in patients with carotid plague group(52.6%vs41.7%) (adjustedP=0.006), as well as the frequency in GG allele of rs4977574 genotype (26.5%vs20.4%) (P=0.002). Strong linkage disequilibrium existed not only between rs10757274 and rs4977574, but also between rs7044859 and rs496892.Conclusions:Genetic polymorphism of rs4977574 on 9p21 is potentially associated with carotid plaque in patients with non-cardioembolic cerebral infarction in Xinjiang and Shanghai.

Key words:Carotid plaque,Single nucleotide polymorphisms,9p21,Cerebral infarction

CLC Number:

R743.3

MAIMAITI Yiming, RE Xidan, CHEN Bo, ZHANG Xiang, MA Weiying, YANG Kang, FU Yi. Analysis on relationship between polymorphism of chromosome region 9p21 and susceptibility of carotid plaque in acute non-cardioembolic cerebral infarction patients[J]. Journal of Diagnostics Concepts & Practice, 2016, 15(05): 498-502.

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