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Magali Mathieu

Centre national de la recherche scientifique

54

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2037

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KRAS G12C fragment screening renders new binding pockets.

2021 Small GTPases
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An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics.

2021 mAbs
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Fast NMR methods for measuring in direct and/or competition mode the dissociation binding constants of chemical fragments interacting with a receptor

2019 ChemMedChem
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Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

2019 Journal of Medicinal Chemistry
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Abstract P-45: Structural Studies of Multispecific Antibody/Antigen Complexes by Cryo-EM

2019 International Journal of Biomedicine
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Chapter Twenty-Six - In Vitro Characterization of VPS34 Lipid Kinase Inhibition by Small Molecules

2017 Methods in Enzymology
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Crystal structure of VPS34 in complex with (2S)-8-((3R)-3- Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3, 4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one, processed with the CrystalDirect automated mounting and cryo-cooling technology

2016
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Crystal structure of CDK2 processed with the CrystalDirect automated mounting and cryo-cooling technology

2016
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Abstract 1198: Characterization of a novel maytansinoid-antibody-drug conjugate targeting LAMP1 expressed at the surface of tumor cells

2016 Cancer Research
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Crystal structure of CDK2 in complex with 2,4,6-trioxo-1-phenyl- hexahydropyrimidine-5-carboxamide processed with the CrystalDirect automated mounting and cryo-cooling technology

2016
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