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Meher Majety

Hoffmann-La Roche

9

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587

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A drug development perspective on targeting tumor-associated myeloid cells

2018 FEBS Journal
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Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model

2017 PLOS ONE
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RG7386, a novel tetravalent FAP-DR5 antibody, effectively triggers FAP-dependent, avidity-driven DR5 hyperclustering and tumor cell apoptosis

2016 Molecular Cancer Therapeutics
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Abstract 952: Induction of avidity-driven hyperclustering of DR5 by a new FAP-DR5 bispecific antibody (RG7386) leads to strong anti-tumor efficacy

2015 Cancer Research
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Fibroblasts Influence Survival and Therapeutic Response in a 3D Co-Culture Model.

2015 PLOS ONE
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Abstract 4573: A novel bispecific Fap-Dr5 antibody inducing potent and tumor-specific death receptor 5 (Dr5) activation by fibroblast activation protein (Fap)-dependent crosslinking

2014 Cancer Research
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A novel bispecific EGFR/Met antibody blocks tumor-promoting phenotypic effects induced by resistance to EGFR inhibition and has potent antitumor activity

2013 Oncogene
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Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance

2009 BMC Systems Biology
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Novel cancer relevant cell cycle modulators identified in automated cell-based assays

2005 European Journal of Cell Biology
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