Abstract:Objective To make an animal model of the simple abdominal wall blast injury with visceral exposure and to observe its long-term changes.Methods Twelve white rabbits of 8-10 weeks were randomly divided into two groups,and injured parts were marked under general anesthesia.A group:self-made enterocoelia protective device with 0.125 g TNT equivalent explosives ball on the site of injury;B Group:the same explosion source of injury without protective device.After injury,autopsy and pathologic examination were used to evaluate the animal model.Results Both groups of animal injury parts presented whole layer blast injury of abdominal wall was observed in both groups.The wound area of A group was(3.9+0.56) cm2,and B group was(3.83±0.49) cm2.There were no significant differences between the two groups(P>0.05).The survival time of A group was(141±87.78) h and B group was(3.67±2.25) h.There were significant differences between group A and Group B(P<0.05).The survival time of experimental group was longer in group A than group B.Autopsy and pathologic examination showed that the reasons for the early death in the group B was visceral injury and abdominal bleeding,while besides fiber adhesion,there was no obvious trauma on visceral in group A.Conclusion This experiment simulated the mechanism of abdominal wall blast injury.An animal model of simple abdominal wall blast injury with protective device can be used for long-term observation with effective protection.

Key words:Blast injury,Animal model,Restore,Long-time observation,Abdominal wall