ObjectiveTo evaluate the efficacy of intraoperative negative pressure drainage in preventing seroma after laparoscopic totally extraperitoneal (TEP) hernia repair.MethodsA total of 200 patients undergoing TEP repair in our hospital from January 2022 to December 2022 were divided into two groups (n=100 each). The study group received intraoperative negative pressure drainage, while the control group did not. Therapeutic outcomes and postoperative complications were compared between the two groups.ResultsThere were no significant differences between the two groups in operative time, pain scores, incidence of wound infection, or recurrence rates (P> 0.05). However, the study group showed a significantly lower incidence of postoperative seroma compared to the control group (P< 0.05). For direct hernias, the operative time in the study group was significantly shorter than that in the control group (P< 0.05). No mesh infections were observed in either group.ConclusionsProphylactic negative pressure drainage significantly reduces seroma formation without increasing other postoperative complications and is easy to be performed. The application of negative pressure drainage is recommended in cases of scrotal and direct hernias.