Advances in the study of intestinal microecology in the development of hepatocellular carcinoma and its implications for clinical diagnosis and treatment

Abstract

Abstract:

The intestinal microecology is closely related to the occurrence and development of hepatocellular carcinoma (HCC). The intestinal microbiota and its metabolites can regulate the tumor immune microenvironment through the "gut-liver axis", promoting cancer progression. Therefore, the intestinal microbiome is gradually demonstrating the potential as a biomarker for early diagnosis of HCC and prediction of the efficacy of immunotherapy. Targeted intervention on the intestinal microecology (such as probiotics, fecal microbiota transplantation, dietary regulation,etc.) may enhance the efficacy of immune checkpoint inhibitors (ICIs) and is becoming a promising combination therapy strategy. In the future, HCC treatment will rely on multi-omics integration, artificial intelligence-assisted diagnosis, and synthetic biology tools to promote the translation of precise gut flora intervention strategies from basic research to the clinic. This article summarized the latest research progress of intestinal microecology in HCC, explored its potential value and development direction for precision diagnosis and treatment of HCC, and provided a theoretical basis for the clinical application of related intervention strategies.

Key words:Intestinal microecology,Hepatocellular carcinoma(HCC),Intestinal microbiome

CLC Number:

R735.7

ZHANG Tianqi, LIU Yang, WEI Yunwei. Advances in the study of intestinal microecology in the development of hepatocellular carcinoma and its implications for clinical diagnosis and treatment[J]. Journal of Surgery Concepts & Practice, 2025, 30(05): 450-455.

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