Advances in endoscopic ultrasound-guided celiac plexus neurolysis and its derivative techniques

Abstract

Abstract:

This review systematically summarizes the clinical applications and recent advances of endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) and its derived techniques. It addressed the indications, contraindications, technical challenges, and procedural principles, with a detailed overview of unilateral and bilateral injection, EUS-guided celiac ganglia neurolysis (EUS-CGN), EUS-guided broad-plexus neurolysis (EUS-BPN), as well as radiofrequency ablation and radioactive seed implantation. In addition, complications and their preventive strategies were discussed, and future directions were highlighted, aiming to provide technical references and decision-making guidance for clinical practice.

Key words:Endoscopic ultrasound (EUS),Celiac plexus neurolysis (CPN),Cancer pain,Ganglion injection,Radiofrequency ablation (RFA)

CLC Number:

R573

AO Xinyi, LI Li, LI Zhi, WANG Kaixuan. Advances in endoscopic ultrasound-guided celiac plexus neurolysis and its derivative techniques[J]. Journal of Surgery Concepts & Practice, 2025, 30(05): 378-384.

Figures/Tables1

Tab 1

Research progress in EUS‑CPN and its derivative techniques

技术分类	例数	疼痛缓解率	疼痛评分	参考文献
单侧比双侧注射	646例	/	单侧/双侧 (P=0.20)	[ 18 ]
	662例	单侧/双侧： 70%/74% （P>0.05）	/	[ 19 ]
	727例	单侧/双侧： 67%/68% （P>0.05）	/	[ 20 ]
	60例	/	单侧/双侧： 12.3/13.0 （P=0.88）	[ 21 ]
	980例	单侧/双侧： 66%/57% （P>0.05）	/	[ 22 ]
	160例	单侧/双侧： 45.9%/70.4% （P=0.001 6）	/	[ 23 ]
EUS-CGN	17例	94%	/	[ 24 ]
EUS-CGN	382例	83%	/	[ 25 ]
EUS-CGN比EUS-CPN	68例	CGN/CPN： 73.5%/45.5% （P=0.026）	/	[ 26 ]
	64例	CGN/CPN： 65%/25% （P=0.002）	/	[ 27 ]
	41例	CGN/CPN： 65.4%/53.3% （P=0.041 4）	/	[ 28 ]
EUS-CGN+EUS-CPN 比EUS-CPN	51例	CPN/CPN+CGN： 0/34.1% （P=0.045）	/	[ 29 ]

Tab 1

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