代谢外科视角下GLP-1受体激动剂在肥胖症术后联合治疗中的应用

摘要/Abstract

摘要：

肥胖全球患病率持续上升，伴随多种代谢并发症。代谢手术虽疗效显著，但仍存在临床效果欠佳、复发性体重增加等问题。胰高血糖素样肽1（GLP-1）受体激动剂优越的代谢调节作用使其成为减重治疗新选择。本文系统探讨代谢手术联合GLP-1受体激动剂的临床应用框架，包括目标人群（如术后体重复增、糖尿病未缓解或合并并发症者）、干预时机与药物选择策略，以及多学科协作路径。联合治疗虽前景广阔，但仍面临最优治疗策略、长期安全性及成本效益等挑战。未来需通过多学科协作和个体化方案，优化肥胖症的长期有效管理。

关键词:肥胖,代谢手术,胰高血糖素样肽1

Abstract:

The global prevalence of obesity continues to rise, accompanied by various metabolic complications. While metabolic surgery has significant efficacy, there are still problems, such as suboptimal clinical outcomes and recurrent weight gain. The superior metabolic regulatory of glucagon-like peptide-1 (GLP-1) receptor agonists has made them a new option for bariatric treatment. This article systematically explored the clinical application framework of combining metabolic surgery with GLP-1 receptor agonists, including target populations (e.g., patients with postoperative weight regain, unremitted diabetes, or comorbid complications), intervention timing, drug selection strategies, and multidisciplinary collaboration pathways. Although combination therapy holds broad prospects, it still faces challenges, such as optimal treatment strategies, long-term safety, and cost-effectiveness. We should emphasize multidisciplinary collaboration and individualized plans to optimize the long-term effective management of obesity in the future.

Key words:Obesity,Metabolic surgery,Glucagon-like peptide-1(GLP-1)

中图分类号:

孟化, 宋宇佳, 王思奇. 代谢外科视角下GLP-1受体激动剂在肥胖症术后联合治疗中的应用[J]. 外科理论与实践, 2025, 30(03): 207-213.

MENG Hua, SONG Yujia, WANG Siqi. Application of GLP-1 receptor agonists in postoperative combined therapy for obesity: a perspective of metabolic surgery[J]. Journal of Surgery Concepts & Practice, 2025, 30(03): 207-213.

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