肝细胞肝癌甲状腺转移（附1例报告）

摘要/Abstract

摘要：

观察1例颈前区巨大占位病人的治疗经过，病理检查提示为肝细胞肝癌（HCC）甲状腺转移。术后病人因出现呼吸困难行气管切开及气切套管置入术。HCC甲状腺转移临床上罕见，其转移原因包括血行转移、淋巴转移等多种因素。乙型肝炎病毒（HBV）感染在肿瘤进展中也起着重要作用。结合文献复习，手术切除甲状腺治疗转移性甲状腺恶性肿瘤可延长生存期，临床工作中仍需制定合理、规范、综合性的诊疗策略，以改善病人的生活质量，提高治疗效果。

关键词:肝细胞肝癌甲状腺转移,甲状腺巨大肿物,乙型肝炎病毒,气管切开

Abstract:

We reported a case with huge mass in the anterior neck region, which pathological diagnosis was thyroid metastasis from hepatocellular carcinoma(HCC). A tracheotomy was performed, and a tracheostomy tube was placed because of postoperative dyspnea. Thyroid metastasis from HCC is very rare. The causes include hematogenous metastasis, lymphatic metastasis and other factors. Furthermore, Hepatitis B virus (HBV) infection also plays an important role in tumor progression. Combined with the literature review, surgical resection of thyroid in the treatment of metastatic thyroid malignant tumors can prolong the survival. In clinical work, it is still necessary to develop a reasonable, standardized and comprehensive diagnosis and treatment strategy to improve the quality of life of patients and the therapeutic efficacy.

Key words:Thyroid metastasis from hepatocellular carcinoma (HCC),Giant thyroid goiter,Hepatitis B virus,Tracheotomy

中图分类号:

李昂, 韩肖骅, 殷晓星. 肝细胞肝癌甲状腺转移（附1例报告）[J]. 外科理论与实践, 2025, 30(01): 66-69.

LI Ang, HAN Xiaohua, YIN Xiaoxing. Thyroid metastasis from hepatocellular carcinoma: a case report[J]. Journal of Surgery Concepts & Practice, 2025, 30(01): 66-69.

图/表4

参考文献19

[1]	戴瑾瑶, 曹君. 甲状腺转移癌研究进展[J].浙江中西医结合杂志,2020,30(4):338-341.
	DAI J Y, CAO J. Research progress on thyroid metastatic carcinoma[J].Zhejiang Integr Tradit Chin West Med,2020,30(4):338-341.
[2]	HEGEROVA L, GRIEBELER M L, REYNOLDS J P, et al. Metastasis to the thyroid gland: report of a large series from the Mayo Clinic[J].Am J Clin Oncol,2015,38(4):338-342.
[3]	MASUDA T, FUKUYA T, ONO M, et al. Thyroid metastasis from hepatocellular carcinoma as an initial presentation: a case report[J].Radiat Med,2001,19(1):43-46. pmid:11305618
[4]	TOSHIMA T, TAKETOMI A, SHIRABE K, et al. Solitary asymptomatic thyroid metastasis from hepatocellular carcinoma detected by FDG-PET/CT[J].Case Rep Gastroenterol,2010,4(2):279-285. doi:10.1159/000318858pmid:21383951
[5]	RUSSELL J O, YAN K, BURKEY B, et al. Nonthyroid metastasis to the thyroid gland: case series and review with observations by primary pathology[J].Otolaryngol Head Neck Surg,2016,155(6):961-968. pmid:27329421
[6]	石东亮, 戴殿禄, 崔国忠, 等. 甲状腺转移性肝细胞癌1例[J].中华耳鼻咽喉头颈外科杂志,2022,57(10):1245-1247.
	SHI D L, DAI D L, CUI G Z, et al. Thyroid metastasis from hepatocellular carcinoma: a case report[J].Chin J Otorhinolaryngol Head Neck Surg,2022,57(10):1245-1247.
[7]	柴佳威, 朱坤兵, 张华伟, 等. 1例肝细胞肝癌甲状腺转移罕见病例报道与文献回顾[J].山东大学学报(医学版),2021,59(3):120-124.
	CHAI J W, ZHU K B, ZHANG H W. A rare case report of hepatocellular carcinoma with thyroid metastasis and literature review[J].J Shandong Univ(Health Sci),2021,59(3):120-124.
[8]	PARK J Y, YI S Y, KWON T, et al. Sonographic diagnosis of thyroid metastasis from hepatocellular carcinoma[J].J Clin Ultrasound,2019,47(1):44-46. doi:10.1002/jcu.22652pmid:30393879
[9]	SUNG T Y, LEE S R, LEE J H, et al. Hepatocellular carcinoma eats medullary thyroid carcinoma, a case of tumor-in-tumor metastasis[J].Endocr J,2011,58(9):801-805.
[10]	张洪义, 邢颖. 肝脏恶性肿瘤综合治疗进展[J].中国临床医生杂志,2022,50(5):505-508.
	ZHANG H Y, XING Y. Advances in comprehensive treatment of malignant liver tumors[J].Chin J Clin,2022,50(5):505-508.
[11]	张蔡羽天, 邱虎, 蔡高科, 等. 放射治疗在原发性肝癌中的研究进展[J].武汉大学学报(医学版),2024,45(2):248-252.
	ZHANG C Y T, QIU H, CAI G K, et al. Research progress of radiotherapy in primary liver cancer[J].Med J Wuhan Univ,2024,45(2):248-252.
[12]	杨林, 唐慎康, 胡泽玉, 等. 原发性肝癌化学药物治疗的研究现状与进展[J].胃肠病学和肝病学杂志,2023,32(7):833-836.
	YANG L, TANG S K, HU Z Y, et al. Current status and progress of chemotherapy for primary liver cancer[J].Chin J Gastroenterol Hepatol,2023,32(7):833-836.
[13]	魏武斌, 马子骞, 孟琳慧, 等. 甲状腺转移癌的临床特点(附11例病例)[J].中日友好医院学报,2022,36(4):226-228,231.
	WEI W B, MA Z Q, MENG L H. Clinical characteristics of thyroid metastatic carcinoma: a report of 11 cases[J].J China-Japan Friendship Hosp,2022,36(4):226-228,231.
[14]	LACKA K, BREBOROWICZ D, ULIASZ A, et al. Thyroid metastases from a breast cancer diagnosed by fine-needle aspiration biopsy. Case report and overview of the literature[J].Exp Oncol,2012,34(2):129-133. pmid:23013767
[15]	LIANG H H, WU C H, TAM K W, et al. Thyroid metastasis in a patient with hepatocellular carcinoma: case report and review of literature[J].World J Surg Oncol,2007,5:144.
[16]	赵海潮, 高强. 2022年度肝癌研究及诊疗新进展[J].中国癌症杂志,2023,33(4):315-326. doi:10.19401/j.cnki.1007-3639.2023.04.002
	ZHAO H C, GAO Q. Progress in research, diagnosis, and treatment of hepatocellular carcinoma in 2022[J].China Oncol,2023,33(4):315-326.
[17]	曲超, 刘奎, 王一休, 等. 乙型肝炎病毒感染及抗病毒治疗对肝细胞癌微血管侵犯的影响[J].中国普通外科杂志,2019,28(1):10-17.
	QU C, LIU K, WANG Y X. Impact of hepatitis B virus infection and antiviral therapy on microvascular invasion in hepatocellular carcinoma[J].Chin J Gen Surg,2019,28(1):10-17.
[18]	王芳芳, 张国范, 王琪, 等. HBV感染原发性肝癌患者GP73和AFU与25(OH)D3及其与TACE术后复发转移的关系[J].中华医院感染学杂志,2023,33(11):1660-1664.
	WANG F F, ZHANG G F, WANG Q, et al. GP73, AFU and 25(OH)D 3 in patients with HBV infection and primary liver cancer and their association with recurrence and metastasis after TACE[J].Chin J Nosocomiol,2023,33(11):1660-1664.
[19]	LE Q V, NGUYEN H V, MAI N T K, et al. Surgical treatment result of giant thyroid tumor: case series in Vietnam[J].Int J Surg Case Rep,2019,54:103-107.