减重手术在肥胖合并Prader-Willi综合征病人的应用效果

摘要/Abstract

中图分类号:

R589.2

陈国骥, 杨华, 王存川. 减重手术在肥胖合并Prader-Willi综合征病人的应用效果[J]. 外科理论与实践, 2020, 25(03): 263-268.

CHEN Guoji, YANG Hua, WANG Cunchuan. Outcomes of bariatric surgery in obese patients with Prader-Willi syndrome[J]. Journal of Surgery Concepts & Practice, 2020, 25(03): 263-268.

图/表1

表1

PWS病人减重手术前、后情况（n=11）

文献	发表年份	例数	术前基本情况	术前体重(kg)/BMI	术式	随访时间	EWL	术后疗效
吴佳君等^{[ 31 ]}	2011	1	男,18岁,2 型糖尿病、高血压病、高脂血症和OSAS	109/45.4	SG	4个月	26.5% （减重13 kg）	无并发症发生,血糖、肝功能等指标改善,胰岛素用量减少
高蔚等^{[ 32 ]}	2012	1	男,13岁,重度OSAS	160	LSG	NA	NA	NA
Fong等^{[ 33 ]}	2012	3	女2例,男1例,（18.7±4.0）（15~23）岁,轻度至中度 OSAS,女1例合并食管炎和食管裂孔疝,空腹血浆 Ghrelin：1134.2±1 704.7 （294.9~2 247.5）ng/L	96.4~120.7/44~50	LMGB（1例） LSG（2例）	24个月	平均63.2%± 20.0%（50.5%~ 86.2%）	空腹血浆Ghrelin： 519.8±593.1(119.7~ 1201.2）ng/L,LMGB术后1年出现缺铁性贫血,摄食行为改善
Yu等^{[ 34 ]}	2013	1	女,17岁,2型糖尿病,呼吸困难,重度OSAS	94.2/46.7	LSG	15个月	61.2%（减重 26.8 kg）	无术后并发症发生,2型糖尿病完全缓解,余并发症改善明显
Liu等^{[ 35 ]}	2020	5	男2例,女3例,19.2±3.0（15~23）岁,2型糖尿病（2例）、OSAS（5例）	96.6±18.8（68.4~ 120.7）/47.3±6.9 （38.4~57.4）	LSG(2例) OAGB(2例) LRYGB(1例)	3例10年,2例6年	术后6年19.7%± 20.8%（1.4%~ 42.7%）,术后 10年-1.2%±3.9% （-1.3%~5.7%）	术后10年并发症无明显改善,2例新发高血压病。1例OAGB术后 78个月（27岁）疑因睡眠中呼吸暂停死亡

表1

参考文献59

[1]	Cassidy SB, Schwartz S, Miller JL, et al. Prader-Willi syndrome[J]. Genet Med, 2012, 14(1):10-26.
[2]	Lionti T, Reid SM, White SM, et al. A population-based profile of 160 Australians with Prader-Willi syndrome: trends in diagnosis, birth prevalence and birth characte-ristics[J]. Am J Med Genet A, 2015, 167A(2):371-378. doi:10.1002/ajmg.a.36845pmid:25424396
[3]	中华医学会儿科学分会内分泌遗传代谢学组, 《中华儿科杂志》编辑委员会. 中国Prader-Willi综合征诊治专家共识(2015)[J]. 中华儿科杂志, 2015, 53(6):419-424.
[4]	Crino A, Fintini D, Bocchini S, et al. Obesity management in Prader-Willi syndrome: current perspectives[J]. Diabetes Metab Syndr Obes, 2018, 11:579-593. doi:10.2147/DMSO.S141352 URL
[5]	Kim Y, Wang SE, Jiang YH. Epigenetic therapy of Prader-Willi syndrome[J]. Transl Res, 2019, 208:105-118. doi:10.1016/j.trsl.2019.02.012 URL
[6]	Butler MG, Kimonis V, Dykens E, et al. Prader-Willi syndrome and early-onset morbid obesity NIH rare di-sease consortium: A review of natural history study[J]. Am J Med Genet A, 2018, 176(2):368-375. doi:10.1002/ajmg.a.38582 URL
[7]	Polex-Wolf J, Lam BY, Larder R, et al. Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome[J]. J Clin Invest, 2018, 128(3):960-969. doi:10.1172/JCI97007pmid:29376887
[8]	Bohonowych J, Miller J, McCandless SE, et al. The glo-bal Prader-Willi syndrome registry: development, launch, and early demographics[J]. Genes (Basel), 2019, 10(9):713. doi:10.3390/genes10090713 URL
[9]	Muscogiuri G, Formoso G, Pugliese G, et al. Prader-Willi syndrome: An uptodate on endocrine and metabolic complications[J]. Rev Endocr Metab Disord, 2019, 20(2):239-250. doi:10.1007/s11154-019-09502-2 URL
[10]	McCandless SE, Committee on Genetics. Clinical report-health supervision for children with Prader-Willi syndrome[J]. Pediatrics, 2011, 127(1):195-204. doi:10.1542/peds.2010-2820pmid:21187304
[11]	Kimonis VE, Tamura R, Gold JA, et al. Early diagnosis in Prader-Willi syndrome reduces obesity and associated co-morbidities[J]. Genes (Basel), 2019, 10(11):898 doi:10.3390/genes10110898 URL
[12]	Khan MJ, Gerasimidis K, Edwards CA, et al. Mechanisms of obesity in Prader-Willi syndrome[J]. Pediatr Obes, 2018, 13(1):3-13. doi:10.1111/ijpo.12177pmid:27863129
[13]	Tauber M, Coupaye M, Diene G, et al. Prader-Willi syndrome: A model for understanding the ghrelin system[J]. J Neuroendocrinol, 2019, 31(7):e12728.
[14]	Feigerlova E, Diene G, Conte-Auriol F, et al. Hyperghrelinemia precedes obesity in Prader-Willi syndrome[J]. J Clin Endocrinol Metab, 2008, 93(7):2800-2805. doi:10.1210/jc.2007-2138 URL
[15]	Dykens EM, Roof E, Hunt-Hawkins H. Cognitive and adaptive advantages of growth hormone treatment in children with Prader-Willi syndrome[J]. J Child Psychol Psychiatry, 2017, 58(1):64-74. doi:10.1111/jcpp.12601 URL
[16]	Stipancic G, Pozgaj Sepec M, La Grasta Sabolic L. Effect of growth hormone therapy in children with Prader-Willi syndrome-our first experiences[J]. Acta Clin Croat, 2018, 57(4):744-755.
[17]	Butler MG, Matthews NA, Patel N, et al. Impact of gene-tic subtypes of Prader-Willi syndrome with growth hormone therapy on intelligence and body mass index[J]. Am J Med Genet A, 2019, 179(9):1826-1835.
[18]	Alsaif M, Elliot SA, MacKenzie ML, et al. Energy metabolism profile in individuals with Prader-Willi syndrome and implications for clinical management: a systematic review[J]. Adv Nutr, 2017, 8(6):905-915. doi:10.3945/an.117.016253pmid:29141973
[19]	Colquitt JL, Pickett K, Loveman E, et al. Surgery for weight loss in adults[J]. Cochrane Database Syst Rev, 2014,(8): CD003641.
[20]	王存川, 张鹏, 杨景哥, 等. 中国儿童和青少年肥胖症外科治疗指南(2019版)[J]. 中华肥胖与代谢病电子杂志, 2019, 5(1): 3-9.
[21]	Bussler S, Penke M, Flemming G, et al. Novel insights in the metabolic syndrome in childhood and adolescence[J]. Horm Res Paediatr, 2017, 88(3-4):181-193. doi:10.1159/000479510 URL
[22]	Shoar S, Mahmoudzadeh H, Naderan M, et al. Long-term outcome of bariatric surgery in morbidly obese adolescents: a systematic review and meta-analysis of 950 patients with a minimum of 3 years follow-up[J]. Obes Surg, 2017, 27(12):3110-3117. doi:10.1007/s11695-017-2738-y URL
[23]	Inge TH, Courcoulas AP, Jenkins TM, et al. Five-year outcomes of gastric bypass in adolescents as compared with adults[J]. N Engl J Med, 2019, 380(22):2136-2145. doi:10.1056/NEJMoa1813909 URL
[24]	Adams TD. In teens with severe obesity, can bariatric surgery wait until adulthood?[J]. N Engl J Med, 2019, 380(22):2175-2177. doi:10.1056/NEJMe1905778 URL
[25]	Schrander-Stumpel CT, Curfs LM, Sastrowijoto P, et al. Prader-Willi syndrome: causes of death in an internatio-nal series of 27 cases[J]. Am J Med Genet A, 2004, 124A(4):333-338. pmid:14735579
[26]	Einfeld SL, Kavanagh SJ, Smith A, et al. Mortality in Prader-Willi syndrome[J]. Am J Ment Retard, 2006, 111(3):193-198. doi:10.1352/0895-8017(2006)111[193:MIPS]2.0.CO;2 URL
[27]	Whittington JE, Holland AJ, Webb T, et al. Population prevalence and estimated birth incidence and mortality rate for people with Prader-Willi syndrome in one UK Health Region[J]. J Med Genet, 2001, 38(11):792-798. pmid:11732491
[28]	Urquhart DS, Gulliver T, Williams G, et al. Central sleep-disordered breathing and the effects of oxygen the-rapy in infants with Prader-Willi syndrome[J]. Arch Dis Child, 2013, 98(8):592-595. doi:10.1136/archdischild-2012-303441pmid:23761691
[29]	Zanella S, Tauber M, Muscatelli F. Breathing deficits of the Prader-Willi syndrome[J]. Respir Physiol Neurobiol, 2009, 168(1-2):119-124. doi:10.1016/j.resp.2009.03.010 URL
[30]	Manzardo AM, Loker J, Heinemann J, et al. Survival trends from the Prader-Willi Syndrome Association (USA) 40-year mortality survey[J]. Genet Med, 2018, 20(1):24-30. doi:10.1038/gim.2017.92pmid:28682308
[31]	吴佳君, 乔洁, 韩兵, 等. 一例Prader-Willi综合征的基因诊断和减重手术治疗[J]. 中华内分泌代谢杂志, 2011, 27(6):498-501.
[32]	高蔚, 顾莺, 罗飞宏, 等. 1例Prader-Willi综合征行腹腔镜袖状胃减容术患儿的护理[J]. 护理学杂志, 2012, 27(24):27-28.
[33]	Fong AK, Wong SK, Lam CC, et al. Ghrelin level and weight loss after laparoscopic sleeve gastrectomy and gastric mini-bypass for Prader-Willi syndrome in Chinese[J]. Obes Surg, 2012, 22(11):1742-1745. doi:10.1007/s11695-012-0725-x URL
[34]	Yu H, Di J, Jia W. Laparoscopic sleeve gastrectomy in Chinese female patient with Prader-Willi syndrome and diabetes[J]. Surg Obes Relat Dis, 2013, 9(2):e25-e27. doi:10.1016/j.soard.2012.07.009 URL
[35]	Liu SY, Wong SK, Lam CC, et al. Bariatric surgery for Prader-Willi syndrome was ineffective in producing sustainable weight loss: Long term results for up to 10 years[J]. Pediatr Obes, 2020, 15(1):e12575.
[36]	Brethauer SA, Kim J, El Chaar M, et al. Standardized outcomes reporting in metabolic and bariatric surgery[J]. Obes Surg, 2015, 25(4):587-606. doi:10.1007/s11695-015-1645-3pmid:25802064
[37]	Oria HE, Moorehead MK. Updated bariatric analysis and reporting outcome system (BAROS)[J]. Surg Obes Relat Dis, 2009, 5(1):60-66. doi:10.1016/j.soard.2008.10.004 URL
[38]	Alqahtani AR, Elahmedi MO, Al Qahtani AR, et al. Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study[J]. Surg Obes Relat Dis, 2016, 12(1):100-110. doi:10.1016/j.soard.2015.07.014pmid:26431633
[39]	Marceau P, Marceau S, Biron S, et al. Long-term expe-rience with duodenal switch in adolescents[J]. Obes Surg, 2010, 20(12):1609-1616. doi:10.1007/s11695-010-0262-4pmid:20835899
[40]	Musella M, Milone M, Leongito M, et al. The mini-gastric bypass in the management of morbid obesity in Prader-Willi syndrome: a viable option?[J]. J Invest Surg, 2014, 27(2):102-105. doi:10.3109/08941939.2013.832824pmid:24063639
[41]	Cazzo E, Gestic MA, Utrini MP, et al. Bariatric surgery in individuals with severe cognitive impairment: report of two cases[J]. Sao Paulo Med J, 2018, 136(1):84-88. doi:10.1590/1516-3180.2016.0299071216 URL
[42]	Martinelli V, Chiappedi M, Pellegrino E, et al. Laparoscopic sleeve gastrectomy in an adolescent with Prader-Willi syndrome: psychosocial implications[J]. Nutrition, 2019, 61:67-69. doi:S0899-9007(18)30249-1pmid:30703571
[43]	Pratt JSA, Browne A, Browne NT, et al. ASMBS pediatric metabolic and bariatric surgery guidelines, 2018[J]. Surg Obes Relat Dis, 2018, 14(7):882-901. doi:10.1016/j.soard.2018.03.019 URL
[44]	Gibbons E, Casey AF, Brewster KZ. Bariatric surgery and intellectual disability: Furthering evidence-based practice[J]. Disabil Health J, 2017, 10(1):3-10. doi:S1936-6574(16)30133-9pmid:27720223
[45]	Randolph JG, Weintraub WH, Rigg A. Jejunoileal bypass for morbid obesity in adolescents[J]. J Pediatr Surg, 1974, 9(3):341-345. pmid:4843988
[46]	Laurent-Jaccard A, Hofstetter JR, Saegesser F, et al. Long-term result of treatment of Prader-Willi syndrome by scopinaro's bilio-pancreatic diversion. study of three cases and the effect of dextrofenfluramine on the posto-perative evolution[J]. Obes Surg, 1991, 1(1):83-87. pmid:10715667
[47]	Marinari GM, Camerini G, Novelli GB, et al. Outcome of biliopancreatic diversion in subjects with Prader-Willi syndrome[J]. Obes Surg, 2001, 11(4):491-495. pmid:11501362
[48]	Vilallonga R, Moreno Villares JM, Yeste Fernandez D, et al. Initial approach to childhood obesity in spain. a multisociety expert panel assessment[J]. Obes Surg, 2017, 27(4):997-1006. doi:10.1007/s11695-016-2413-8pmid:27752806
[49]	王勇, 王存川, 朱晒红, 等. 中国肥胖及2型糖尿病外科治疗指南(2019版)[J]. 中国实用外科杂志, 2019, 39(4):301-306.
[50]	Papavramidis ST, Kotidis EV, Gamvros O. Prader-Willi syndrome-associated obesity treated by biliopancreatic diversion with duodenal switch. Case report and literature review[J]. J Pediatr Surg, 2006, 41(6):1153-1158. pmid:16769352
[51]	de Almeida MQ, Cercato C, Rascovski A, et al. Results of biliopancreatic diversion in two patients with Prader-Willi syndrome[J]. Obes Surg, 2005, 15(6):901-904. doi:10.1381/0960892054222885 URL
[52]	Grugni G, Guzzaloni G, Morabito F. Failure of biliopancreatic diversion in Prader-Willi syndrome[J]. Obes Surg, 2000, 10(2):179-182. pmid:10782182
[53]	Antal S, Levin H. Biliopancreatic diversion in Prader-Willi syndrome associated with obesity[J]. Obes Surg, 1996, 6(1):58-62. pmid:10731252
[54]	Brossy JJ. Biliopancreatic bypass in the Prader-Willi syndrome[J]. Br J Surg, 1989, 76(3):313. doi:10.1002/bjs.1800760331 URL
[55]	Robert M, Espalieu P, Pelascini E, et al. Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for obesity (YOMEGA): a multicentre, randomised, open-label, non-inferiority trial[J]. Lancet, 2019, 393(10178):1299-1309. doi:S0140-6736(19)30475-1pmid:30851879
[56]	Kobayashi J, Kodama M, Yamazaki K, et al. Gastric bypass in a Japanese man with Prader-Willi syndrome and morbid obesity[J]. Obes Surg, 2003, 13(5):803-805. pmid:14627483
[57]	Thuilleaux D, Laurier V, Copet P, et al. A model to characterize psychopathological features in adults with Prader-Willi syndrome[J]. Am J Med Genet A, 2018, 176(1):41-47. doi:10.1002/ajmg.a.38525pmid:29150898
[58]	Galioto R, Gunstad J, Heinberg LJ, et al. Adherence and weight loss outcomes in bariatric surgery: does cognitive function play a role?[J]. Obes Surg, 2013, 23(10):1703-1710. doi:10.1007/s11695-013-1060-6pmid:23934274
[59]	Mason EE, Maher JW, Scott DH. Ten years of vertical banded gastroplasty for severe obesity[J]. Probl Gen Surg, 1992, 9:280-289.

减重手术在肥胖合并Prader-Willi综合征病人的应用效果

Outcomes of bariatric surgery in obese patients with Prader-Willi syndrome

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