Progress in diagnosis and treatment of oral ulcer with traditional Chinese medicine and Western medicine

Abstract

Abstract:

Oral ulcer is a common oral mucosal disease, the pathogenesis of it is complex. It may relate to genetics, immune disorders, nutritional deficiency, infection, drug response and psychological factors, while currently there is no specific treatment for the disease. In recent years, the research on the treatment of oral ulcers with traditional Chinese medicine has gradually increased, especially the combination of traditional Chinese medicine and Western medicine has showed a good application prospect. The article reviews the diagnosis and treatment of oral ulcer with traditional Chinese medicine and Western medicine to explore new ideas for further promotion relevant clinical research.

Key words:Oral ulcer,Syndrome differentiation,Aphtha

CLC Number:

R781

WU Jingyi, WANG Xiaoli, CHEN Jie, ZHENG Lan. Progress in diagnosis and treatment of oral ulcer with traditional Chinese medicine and Western medicine[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(01): 84-88.

References42

[1]	Edgar NR, Saleh D, Miller RA. Recurrent aphthous stomatitis: a review[J].J Clin Aesthet Dermatol,2017,10(3):26-36.
[2]	Cui RZ, Bruce AJ, Rogers RS 3rd. Recurrent aphthous stomatitis[J].Clin Dermatol,2016,34(4):475-481. doi:10.1016/j.clindermatol.2016.02.020pmid:27343962
[3]	Tarakji B, Gazal G, Al-Maweri SA, et al. Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners[J].J Int Oral Health,2015,7(5):74-80.
[4]	Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis[J].Dent Clin North Am,2014,58(2):281-297.
[5]	Chattopadhyay A, Shetty KV. Recurrent aphthous stomatitis[J].Otolaryngol Clin North Am,2011,44(1):79-88.
[6]	Lau CB, Smith GP. Recurrent aphthous stomatitis: a comprehensive review and recommendations on therapeutic options[J].Dermatol Ther,2022,35(6):e15500.
[7]	Chattopadhyay A, Chatterjee S. Risk indicators for recurrent aphthous ulcers among adults in the US[J].Community Dent Oral Epidemiol,2007,35(2):152-159.
[8]	Slebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review[J].Arch Immunol Ther Exp (Warsz),2014,62(3):205-215.
[9]	Pincelli T, Butendieck RR Jr, Heckman MG, et al. Apremilast for severe recurrent aphthous stomatitis: a prospective pilot study[J].J Am Acad Dermatol,2023,88(2):459-461.
[10]	Thornhill MH, Baccaglini L, Theaker E, et al. A randomized, double-blind, placebo-controlled trial of pentoxifylline for the treatment of recurrent aphthous stomatitis[J].Arch Dermatol,2007,143(4):463-470. doi:10.1001/archderm.143.4.463pmid:17438178
[11]	O’Neill ID, Scully C. Biologics in oral medicine: ulcerative disorders[J].Oral Dis,2013,19(1):37-45. doi:10.1111/j.1601-0825.2012.01931.xpmid:22471882
[12]	Yilmaz HG, Albaba MR, Caygur A, et al. Treatment of recurrent aphthous stomatitis with Er,Cr:YSGG laser irradiation: a randomized controlled split mouth clinical study[J].J Photochem Photobiol B,2017,170:1-5.
[13]	宋梧桐, 施丽婕. 从五脏整体观辨证论治复发性口腔溃疡验案1则[J].中国中医药现代远程教育,2021,19(5):133-135.
[14]	刘晓慧, 刘永红, 张晓光, 等. 甘草泻心汤加味治疗寒热错杂型复发性口腔溃疡疗效及机制研究[J].现代中西医结合杂志,2021,30(12):1300-1304.
[15]	汪绂.医林纂要探源[M]. 北京: 中国中医药出版社,2015:87.
[16]	王好古.汤液本草[M]. 北京: 中国中医药出版社,2013:42-43.
[17]	尚志钧.名医别录辑校本[M]. 北京: 中国中医药出版社,2013:98-99.
[18]	李时珍.本草纲目[M]. 山西: 山西科学技术出版社,2014:585-586.
[19]	石莉. 复发性口腔溃疡中医辨证分型研究概述[J].西部中医药,2023,36(7):154-157.
[20]	辛贺. 复发性口腔溃疡发病机制及中西医结合治疗进展[J].全科口腔医学电子杂志,2019,6(4):119.
[21]	李雪昔. 谈复发性阿弗他口腔溃疡的中医脏腑辨证[J].中华中医药杂志,2019,34(10):4600-4603.
[22]	孟鹏飞, 吴涛, 马秀霞, 等. 甘草泻心汤治疗艾滋病复发性口腔溃疡脾胃湿热证[J].中医学报,2019,34(10):2203-2205.
[23]	李慧, 李怀奇. 复发性口腔溃疡患者免疫指标、铁代谢指标和肿瘤坏死因子的水平变化特点[J].中国现代医学杂志,2020,30(1):41-44.
[24]	熊志刚, 张策策, 王晓伟, 等. 国医大师李士懋温阳法治疗口腔溃疡经验[J].中国中医基础医学杂志,2021,27(9):1483-1486.
[25]	冯兆张.冯氏锦囊秘录[M]. 北京: 人民卫生出版社,1998:200.
[26]	张锡纯.医学衷中参西录[M]. 石家庄: 河北科学技术出版社,2017:349-353
[27]	谭彩霞, 李鉴森, 赖成志, 等. 李俊从脾虚论治复发性口腔溃疡之经验[J].江苏中医药,2021,53(9):41-43.
[28]	方旭琴, 崔向宁, 曲艺, 等. 基于中医传承辅助平台挖掘中药复方专利中治疗复发性口腔溃疡的用药规律[J].世界科学技术-中医药现代化,2022,24(03):1126-1136.
[29]	陈会娟, 毕伟博, 崔红生. 复发性口腔溃疡的郁热病机与六经辨证探析[J].中华中医药杂志,2016,31(8):2989-2992.
[30]	洪燕珠, 奚胜艳, 许家佗, 等. 从“寒饮”论治复发性口腔溃疡临证体会[J].中华中医药杂志,2020,35(2):729-731.
[31]	孙姣. 顽固性口腔溃疡复发的危险因素分析[J].中国烧伤创疡杂志,2022,34(03):225-228.
[32]	罗茫, 刘一平, 李元聪, 等. 4435例口腔黏膜病临床及中医辨治分析[J].中国医药科学,2020,10(4):3-6.
[33]	尚志忠, 王安安, 高晓通, 等. 复发性口腔溃疡的病因学研究进展[J].全科口腔医学电子杂志,2019,6(19):26-27.
[34]	周雨慧, 李晓宁, 宋梦蝶, 等. 中医药治疗复发性口腔溃疡研究进展[J].中医学报,2020,35(6):1207-1211.
[35]	刘晓慧, 刘永红, 张晓光, 等. 甘草泻心汤加味治疗寒热错杂型复发性口腔溃疡疗效及机制研究[J].现代中西医结合杂志,2021,30(12):1300-1304.
[36]	张荣. 口腔科中成药用药情况调查与管理分析[J].中医药管理杂志,2023,31(3):135-137.
[37]	谢峰, 沈丽, 焦露露, 等. 顾氏喉科改良版碧雪散治疗复发性口腔溃疡50例[J].内蒙古中医药,2017,36(15):94-95.
[38]	朱珊. 中西医结合治疗复发性口腔溃疡患者的临床疗效分析[J].中国实用医药,2021,16(26):166-169.
[39]	颜颀. 中西医结合治疗复发性口腔溃疡160例[J].中医药学刊,2004,22(7):1340-1341.
[40]	潘红艳. 中医、西医及中西医结合治疗复发性口腔溃疡的临床对比研究[J].现代中西医结合杂志,2015(3):310-311.
[41]	张春雨. 复发性阿弗他溃疡病因及防治[J].医学食疗与健康,2021,19(28):223.
[42]	蔺晓源, 王瑾茜, 胡国恒. 王行宽教授基于“虚、郁、热”治疗复发性口腔溃疡的临证思路[J].湖南中医药大学学报,2019,39(6):721-724.