Abstract:

Objective:To investigate the value and significance of¹⁸F-prostate-specific membrane antigen (¹⁸F-PSMA)-1007 PET/MR for early diagnosis of recurrence and metastasis in prostate cancer patients after radical prostatectomy (RP).Methods:A total of 143 patients with prostate cancer after radical prostatectomy were enrolled during June 2019 to January 2022 in Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. All the patients underwent¹⁸F-PSMA-1007 PET/MR imaging within 12 to 60 months after surgery. According to the serum prostate-specific antigen (PSA) levels, patients were divided into 5 groups（PSA≤0.2 ng/mL, 0.2 ng/mLResults:The detection rates of¹⁸F-PSMA-1007 PET/MR for recurrence or metastasis in PSA≤0.2 ng/mL, 0.2 ng/mLP<0.01 orP<0.05). In terms of treatment，34 patients (27.64%) changed their pre-examination treatment regimen based on the results of¹⁸F-PSMA-1007 PET/MR imaging.Conclusions:It reveals that prostate patients with detected recurrence or metastasis account for 25% of those with normal PSA level.The detection rate increases with the increase of PSA levels. It suggests that¹⁸F-PSMA PET/MR can detect recurrence and metastasis in the early stage, which can effectively guide the formulation of treatment plans.

Key words:Positron emission tomography computed tomography,Magnetic resonance imaging,Prostate cancer