Diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy for different thyroid carcinoma in 10 388 thyroid nodules: a ten-year study

Abstract

Abstract:

Objective:To investigate the diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy (US-FNAB) in different subtypes of thyroid carcinoma.Methods:A total of 10 388 thyroid nodules from 9 933 patients undergone US-FNAB in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from January 2010 to December 2019 were enrolled, and related data were retrospectively analyzed. The sensitivity, specificity, accuracy, positive and negative predictive value of US-FNAB for thyroid carcinoma were assessed by comparing to the results of surgical pathology. The accuracy rate of diagnosis between different subtypes of thyroid carcinoma was further analyzed.Results:The ten-year study revealed that among 10 388 nodules, 9 379 nodules were malignant. The total sensitivity, specificity, positive and negative predictive value of US-FNAB for thyroid carcinoma were 95.4%, 84.7%, 98.4%, 65.9% and 94.4%, respectively. For the subtypes of thyroid carcinoma, diagnostic accuracies for papillary carcinoma and medullary carcinoma were 95.8% and 69.4%, respectively.Conclusions:US-FNAB is valuable in the diagnosis of thyroid nodules and has the highest diagnostic accuracy for thyroid papillary carcinoma.

Key words:Thyroid carcinoma,Ultrasound-guided fine needle aspiration biopsy,Papillary carcinoma of thyroid

CLC Number:

R736.1

WANG Xing, WANG Ronghui, ZHANG Guiping, DONG Yijie, ZHOU Wei, ZHAN Weiwei. Diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy for different thyroid carcinoma in 10 388 thyroid nodules: a ten-year study[J]. Journal of Diagnostics Concepts & Practice, 2020, 19(04): 359-363.

Figures/Tables2

指标	2010年至2014年	2015年	2016年	2017年	2018年	2019年	总计
灵敏度（%）	95.1	97.4	96.8	95.1	94.8	94.7	95.4
特异度（%）	71.0	81.3	77.8	90.4	88.6	92.1	84.7
阳性预测值（%）	96.8	98.0	98.0	98.8	98.8	99.1	98.4
阴性预测值（%）	61.2	77.0	67.9	68.5	62.6	64.5	65.9
阳性似然比（+）	3.279	5.209	4.355	9.860	8.349	12.015	6.220
阴性似然比（-）	0.069	0.032	0.041	0.054	0.059	0.058	0.054
准确率（%）	92.8	95.8	95.3	94.6	94.2	94.5	94.4
约登指数	0.661	0.787	0.746	0.855	0.834	0.868	0.801

病理类型	2010年至2014	2015年	2016年	2017年	2018年	2019年	总计
乳头状癌（%）	95.4(1 418/1 487)	97.7(952/974)	97.2(1 276/1 313)	95.3(1 577/1 654)	95.2(1 751/1 839)	95.0(1 810/1 906)	95.8(8 784/9 173)
髓样癌（%）	5/7	9/13	8/13	7/10	65.5(19/29)	76.9(20/26)	69.4(68/98)

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