郑科-开云网页登录系统生物医学研究院

学习经历
2007.12 至 2013.07 宾夕法尼亚大学，博士后
2002.09 至 2007.06 浙江大学，博士，遗传学专业
1998.09 至 2002.06 浙江大学，学士，生物技术专业

工作经历
2025.05 至今开云网页登录，系统生物医学研究院，教授
2013.08 至 2025.04 南京医科大学，生殖医学与子代健康全国重点实验室，教授

人才奖项
2015 江苏省杰出青年基金获得者
2015 江苏省特聘教授

学会兼职与审稿人
美国生殖生物学会会刊Biology of Reproduction编委
中国动物学会生殖生物学分会委员

长期从事哺乳动物和人类精子发生机制研究，聚焦非编码RNA、RNA结合蛋白和表观遗传学等方向，重点阐明精子发生过程中的RNA调控机制。研究成果发表于Science、Nat Commun、Genes Dev、Nucleic Acids Res、PNAS、BMC Biol、PLoS Genet等期刊。

1. Li Y, Wang Y, Tan YQ, Yue Q, Guo Y, Yan R, Meng L, Zhai H, Tong L, Yuan Z, Li W, Wang C, Han S, Ren S, Yan Y, Wang W, Gao L, Tan C, Hu T, Zhang H, Liu L, Yang P, Jiang W, Ye Y, Tan H, Wang Y, Lu C, Li X, Xie J, Yuan G, Cui Y, Shen B, Wang C, Guan Y, Li W, Shi Q, Lin G, Ni T, Sun Z, Ye L, Vourekas A, Guo X*, Lin M*, Zheng K*. The landscape of RNA binding proteins in mammalian spermatogenesis. Science 2024 Oct 25; 386(6720): eadj8172. doi: 10.1126/science.adj8172. (corresponding author)
2. Li Y*, Zhai H, Tong L, Wang C, Xie Z, Zheng K*. LncRNA Functional Screening in Organismal Development (review). Non-Coding RNA 2023, 9(4), 36. DOI: 10.3390/ncrna9040036. (corresponding author)
3. Tan H, Wang W, Zhou C, Wang Y, Zhang S, Yang P, Guo R, Chen W, Zhang J, Ye L, Cui Y*, Ni T*, Zheng K*. Single-cell RNA-seq uncovers dynamic processes orchestrated by RNA-binding protein DDX43 in chromatin remodeling during spermiogenesis. Nature Communications 2023 Apr 29;14(1):2499. doi: 10.1038/s41467-023-38199-w. (corresponding author)
4. Ling L, Li F, Yang P, Oates RD, Silber S, Kurischko C, Luca FC, Leu NA, Zhang J, Yue Q, Skaletsky H, Brown LG, Rozen S, Page DC, Wang PJ*, Zheng K*. Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man. Biology of Reproduction 2022 Jul 25;107(1):157-167. doi: 10.1093/biolre/ioac093. (corresponding author)
5. Chen Z, Ling L, Shi X, Li W, Zhai H, Kang Z, Zheng B, Zhu J, Ye S, Wang H, Tong L, Ni J, Huang C*, Yang L*, Zheng K*. Microinjection of antisense oligonucleotides into living mouse testis enables lncRNA function study. Cell & Bioscience 2021 Dec 17;11(1):213. doi: 10.1186/s13578-021-00717-y. (corresponding author)
6. Yin H, Kang Z, Zhang Y, Gong Y, Liu M, Xue Y, He W, Wang Y, Zhang S, Xu Q, Fu K, Zheng B, Xie J, Zhang J, Wang Y, Lin M, Zhang Y, Feng H, Xin C, Guan Y, Huang C, Guo X, P Jeremy Wang, Baur JA, Zheng K*, Sun Z*, Ye L*. HDAC3 controls male fertility through enzyme-independent transcriptional regulation at the meiotic exit of spermatogenesis. Nucleic Acids Research 2021 May 21;49(9):5106-5123. doi: 10.1093/nar/gkab313. (co-corresponding author)
7. Wang W, Tan H, Sun M, Han Y, Chen W, Qiu S, Zheng K*, Wei G*, Ni T*. Independent component analysis based gene co-expression network inference (ICAnet) to decipher functional modules for better single-cell clustering and batch integration. Nucleic Acids Research 2021 May 21;49(9):e54. doi: 10.1093/nar/gkab089. (co-corresponding author)
8. Yu L, He W, Xie J, Guo R, Ni J, Zhang X, Xu Q, Wang C, Yue Q, Li F, Luo M, Sun B*, Ye L*, Zheng K*. In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions. Journal of Visualized Experiments 2019 Jul 17;(149). doi: 10.3791/59830. (corresponding author)
9. Zhang X, Yu L, Ye S, Xie J, Huang X, Zheng K*, Sun B*. MOV10L1 Binds RNA G-Quadruplex in a Structure-Specific Manner and Resolves It More Efficiently Than MOV10. iScience 2019 Jul 26; 17:36-48. doi: 10.1016/j.isci.2019.06.016. Epub 2019 Jun 15. (co-corresponding author)
10. Fu K, Tian S, Tan H, Wang C, Wang H, Wang M, Wang Y, Chen Z, Wang Y, Yue Q, Xu Q, Zhang S, Li H, Xie J, Lin M, Luo M, Chen F, Ye L, Zheng K*. Biological and RNA regulatory function of MOV10 in mammalian germ cells. BMC Biology 2019 May 14; 17(1):39. doi: 10.1186/s12915-019-0659-z. (corresponding author)
11. Xu Q, Wang C, Ling L, Yue Q, Liu M, Zhang S, Fu K, Ye L, Zheng K*. Enhanced Crosslinking Immunoprecipitation (eCLIP) Method for Efficient Identification of Protein-bound RNA in Mouse Testis. Journal of Visualized Experiments 2019 May 10; (147). doi: 10.3791/59681. (corresponding author)
12. Zhu Z, Yue Q, Xie J, Zhang S, He W, Bai S, Tian S, Zhang Y, Xiong M, Sun Z, Huang C, Li Y, Zheng K*, Ye L*. Rapamycin-mediated mTOR inhibition impairs silencing of sex chromosomes and the pachytene piRNA pathway in the mouse testis. Aging (Albany NY) 2019, 11(1): 185-208. doi: 10.18632/aging.101740. (co-corresponding author)
13. Bai S, Fu K, Yin H, Cui Y, Yue Q, Li W, Cheng L, Tan H, Liu X, Guo Y, Zhang Y, Xie J, He W, Wang Y, Feng H, Xin C, Zhang J, Lin M, Shen B, Sun Z, Guo X*, Zheng K*, Ye L*. Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes. Development 2018, 145(13), dev164855. doi:10.1242/dev.164855. (co-corresponding author)
14. Liu M, Zhu C, Bai S, Li X, Fu K, Ye L, Zheng K*. An In Vivo Method to Study Mouse Blood-Testis Barrier Integrity. Journal of Visualized Experiments 2018 Dec 2; (142). doi: 10.3791/58512. (corresponding author)
15. Ye L*, Zheng K*. Roles of mTOR signaling in spermatogenesis (review). Spermatogenesis: Biology and Clinical Implications (book) 2018. (corresponding author)
16. Bai S, Cheng L, Zhang Y, Zhu C, Zhu Z, Zhu R, Cheng CY, Ye L, Zheng K*. A Germline-Specific Role for the mTORC2 Component Rictor in Maintaining Spermatogonial Differentiation and Intercellular Adhesion in Mouse Testis. Molecular Human Reproduction 2018, 1; 24(5): 244-259. (corresponding author)
17. Vourekas A#, Zheng K# *, Fu Q#, Maragkakis M#, Alexiou P, Ma J, Pillai RS, Mourelatos Z*, Wang PJ*. MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes & Development 2015, 29 (6): 617-29. (co-corresponding author)
18. Zheng K#, Wang PJ. Blockade of Pachytene piRNA Biogenesis Reveals a Novel Requirement for Maintaining Post-meiotic Germline Genome Integrity in Mice. PLoS Genetics 2012, 8(11): e1003038
19. Zheng K#, Xiol J#, Reuter M, Eckardt S, Leu NA, McLaughlin KJ, Stark A, Sachidanandam R, Pillai RS, Wang PJ. Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci USA. 2010, 107(26): 11841-11846
20. Zheng K#, Wu X, Kaestner KH, Wang PJ. The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse. BMC Developmental Biology 2009, 9(1): 38
21. Zheng K#, Yang F, Wang PJ. Regulation of male fertility by X-linked genes. J Andrology 2010, 31: 79-85
22. Zheng K#, Pan JW, Ye L, Fu Y, Peng HZ, Wan BY, Gu Q, Bian HW, Han N, Wang JH, Kang B, Pan JH, Shao HH, Wang WZ, Zhu MY. Programmed Cell Death - Involved Aluminum Toxicity in Yeast Alleviated by Antiapoptotic Members with Decreased Calcium Signals. Plant Physiology 2007, 143: 38-49
23. Zheng K#, Pan JW, Jiang ZM, Zhu MY. The assay principle and molecular mechanisms of sister chromatid exchange (SCE). Xi Bao Sheng Wu Xue Za Zhi (Journal of Cell Biology, Chinese journal). 2002, 24: 355-359

1. 国家科技部 “蛋白质机器与生命过程调控”重点专项2016YFA0500900，RNA 结合蛋白在精子发生过程中的作用机理，2016.07-2021.06，子课题负责人
2. 国家科技部“生殖健康及重大出生缺陷防控研究”重点专项2018YFC1003500，精子发生的调节机制，2018.10-2021.09，研究骨干
3. 国家自然科学基金面上项目32170858，剪接因子RBM22调控减数分裂的作用机制研究，2022.01.01-2025.12.31，主持
4. 国家自然科学基金面上项目31970791，RNA解旋酶DDX43调控精子发生的作用机制研究，2020.01.01-2023.12.31，主持
5. 国家自然科学基金面上项目31771653，线粒体蛋白PDHA2在减数分裂和piRNA形成过程中的功能及分子机制，2018.01-2021.12，主持
6. 国家自然科学基金面上项目31471228, MOV10L1介导合成的粗线期piRNA对精子发生表观遗传学的调控作用研究，2015.01-2018.12，主持
7. 江苏省杰出青年基金BK20150047，piRNA合成途径调控精子发生的新机制研究，2015.07-2018.06，主持