学习经历
2010年毕业于浙江大学昆虫开云足球app官方下载安装 所，获得博士学位。

 

工作经历
2014年12月- 至今 开云网页登录 系统生物医学研究院 实验师 高级实验师
2010年 7月-2014年11月 中科院上海生科院营养开云足球app官方下载安装 所 助理研究员

 

 

肿瘤免疫与细胞治疗

1.Dan-Dan He#, Xue-Ying Shang#, Na Wang#, Guang-Xing Wang, Kun-Yan He, Lan Wang，Ze-Guang Han*. BRD4 inhibition induces synthetic lethality in ARID2-deficient hepatocellular carcinoma by increasing DNA damage. Oncogene volume 41, pages1397–1409 (2022)
2.Na Wang#, Lele Song#, Yi Xu#, Longfu Zhang, Yanjun Wu, Jingyu Guo, Weiwei Ji, Jingya Zhao, Xin Zhang, Lixing Zhan*. Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via affecting on Nox2/ROS/Nrf2/PD-L1 signaling. Ebiomedicine. 2019. DOI: 10.1016/j.ebiom.2019.08.057
3.Chen C#, Wang L#, Cui XF, Shang XY, Bai SH, Li L, Wang N, Han ZG*. SCARA5 deficiency inhibits ferroptosis via regulating iron homeostasis and results in sorafenib resistance in hepatocellular carcinoma. Cell Signal. 2025 May:129:111656. doi: 10.1016/j.cellsig.2025.111656. Epub 2025 Feb 13.
4.Xie J#, Lu ZN#, Bai SH#, Cui XF, Lian HY, Xie CY, Wang N, Wang L, Han ZG*. Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence. EMBO J. 2024 Aug 27. doi: 10.1038/s44318-024-00212-3
5.Cui X#, Shang X#, Xie J, Xie C, Tang Z, Luo Q, Wu C, Wang G, Wang N, He K, Wang L, Huang L, Wan B, Roeder RG, Han ZG*. Cooperation between IRTKS and deubiquitinase OTUD4 enhances the SETDB1-mediated H3K9 trimethylation that promotes tumor metastasis via suppressing E-cadherin expression. Cancer Lett. 2023 Sep 20:575:216404.
6.Xianbin Su#*, Linan Zhao#, Yi Shi#, Rui Zhang, Qi Long, Shihao Bai, Qing Luo, Yingxin Lin, Xin Zou, Shila Ghazanfar, Kun Tao, Guoliang Yang, Lan Wang, Kun-Yan He, Xiaofang Cui, Jian He, Jiao-Xiang Wu, Bo Han, Bin Yan, Biao Deng, Na Wang, Xiaolin Li, Pengyi Yang, Shangwei Hou, Jielin Sun, Jean Y H Yang, Jinhong Chen*, Ze-Guang Han*. Clonal evolution in liver cancer at single-cell and single-variant resolution. J Hematol Oncol. 2021 2;14(1):22. doi: 10.1186/s13045-021-01036-y.
7.Jiao-Xiang Wu# , Kun-Yan He#* , Zhuang-Zhuang Zhang , Yu-Lan Qu , Xian-Bin Su , Yi Shi , Na Wang , Lan Wang , Ze-Guang Han*. LZP is required for hepatic triacylglycerol transportation through maintaining apolipoprotein B stability. PLoS Genetics. 2021,17(2): DOI:10.1371/journal.pgen