学习经历
(Education:)
2003.09-2009.07 复旦大学/国家人类基因组南方研究中心 遗传学专业 获博士学位 （硕博连读）
(2003.09-2009.07 Fudan University/Chinese Human Genome Center at Shanghai, PhD in Genetics, Shanghai, China)
1998.09-2002.07 湖北大学 生物工程专业 获学士学位
(1998.09-2002.07 Hubei University, Bachelor of Science in Biology, Wuhan, China)

 

工作经历
(Research Experience:)
2020.10-至今 开云网页登录 系统生物医学研究院 特别研究员/博士生导师
(2020.10-Now, Tenure-track Associated Professor/Principal Investigator, Shanghai Jiao Tong University, Shanghai Center for Systems Biomedicine, Shanghai, China)
2014.09-2020.09 美国纽约纪念斯隆-凯特琳癌症中心 博士后副研究员
(2014.09-2020.09 Postdoctoral Research Associate, Memorial Sloan Kettering Cancer Center [MSKCC], New York, USA)
2009.07-2014.08 美国密西根大学生化系/HHMI 从事博士后研究
(2009.07-2014.08 Postdoctoral Research Fellow, University of Michigan/Howard Hughes Medical Institute, Ann Arbor, Michigan, USA)

 

人才奖项
(Honors:)
2021年入选上海海外高层次人才计划
(Sponsored by the Talent Program of Shanghai Municipality in 2021)
2020年入选开云网页登录 长聘体系(Tenure-Track)教职 (绿色通道引进高层次人才)
(Sponsored by the Talent Program of Shanghai Jiao Tong University in 2020)
2019年入选纪念斯隆-凯特琳癌症中心十大基础研究突破之一
(Selected as 1 of 10 Remarkable Basic Science Breakthroughs of MSKCC in 2019, New York, USA)
2018年获纪念斯隆-凯特琳协会学者奖
(Granted The Society of Memorial Sloan-Kettering Scholars Prize in 2018, New York, USA)

 

学会兼职与审稿人
(Academic Activities:)
Nature出版集团《Scientific Reports》杂志编委 Editorial Board of Scientific Reports
中国生物化学与生物物理学报《Acta Biochimica et Biophysica Sinica》杂志编委 Editorial Board of Acta Biochimica et Biophysica Sinica


中国细胞生物学学会CSCB会员
中国生物化学和分子生物学学会CSBMB会员
AAAS (American Association for the Advancement of Science) 协会会员 (AAAS Membership)
NYAS (New York Academy of Sciences) 协会会员 (NYAS Membership)

审稿人Ad hoc reviewer:
Cell Reports,
Cell Death & Differentiation,
Aging,
J Cancer,
Acta Biochimica et Biophysica Sinica等杂志审稿人
(Ad hoc reviewer of the journals: Cell Reports, Cell Death & Differentiation, Aging, J Cancer, Acta Biochimica et Biophysica Sinica)

DNA损伤修复与端粒的功能研究 (Research Areas: DNA damage repair and telomere biology)
1. 人染色体端粒长度维持的分子机制及其与癌症和衰老的关系研究
(Telomere Maintenance of telomere-binding proteins and its roles in cancer and aging)
2. 维持酵母基因组稳定性起重要作用的DNA损伤修复蛋白的作用机制研究
(Mechanistic studies of the role of DNA damage response protein in genome maintenance of Saccharomyces cerevisiae)
3. 人的肿瘤发生发展密切相关的DNA损伤修复蛋白的作用机制研究与应用
(Mechanistic studies of the association of DNA damage response protein and human tumorigenesis)

(Publications:)
1. Wan B#*, Guan D#, Li S, Chwat-Edelstein T, Zhao X*. Mms22-Rtt107 axis attenuates the DNA damage checkpoint and the stability of the Rad9 checkpoint mediator. Nat Commun. 2025, 16(1):311. PMID: 39746913.

2. Wang X, Gao M, Song J, Li M, Chen Y, Lv Y, Jia W, Wan B*. Differential Expression of tRNA-Derived Small RNA Markers of Antidepressant Response and Functional Forecast of Duloxetine in MDD Patients. Genes. 2025, 16(2):162. PMID: 40004491.

3. Qu H#, Shi X#, Xu Y#, Qin H, Li J, Cai S, Zhao J, Wan B*, Yang Y*, Li B*. Mechanism of Musashi2 affecting radiosensitivity of lung cancer by modulating DNA damage repair. MedComm. 2024, 5(5):e548. PMID: 38645664.

4. Cui X#, Shang X#, Xie J, Xie C, Tang Z, Luo Q, Wu C, Wang G, Wang N, He K, Wang L, Huang L, Wan B, Roeder RG, Han ZG*. Cooperation between IRTKS and deubiquitinase OTUD4 enhances the SETDB1-mediated H3K9 trimethylation that promotes tumor metastasis via suppressing E-cadherin expression. Cancer Lett. 2023, 575:216404. PMID: 37739210.

5. Zhu C, Liang X, Chen X, Liang M, Zheng J, Wan B, Luo S*. Characterizing the Specific Recognition of Xanthurenic Acid by GEP1 and GEP1-GC alpha Interactions in cGMP Signaling Pathway in Gametogenesis of Malaria Parasites. Int J Mol Sci, 2023, 24(3):2561. PMID: 36768882

6. Ma Y, Huang C, Tang T, Wu B, Xue H, Cao Y, Wu J, Wan B* and Lei M*. Structural and functional insights into CST tethering in Tetrahymena thermophila telomerase. Structure, 2022, 30(12):1565-1572. PMID: 36459975. (*corresponding author)

7. Yu Y#, Li S#, Ser Z#, Sanyal T#, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel DJ*, Zhao X*. Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A, 2021, 118(19):e2026844118. PMID: 33941673.

8. Li S#, Bonner JN#, Wan B, So S, Summers A, Gonzalez L, Xue X*, Zhao X*. Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes Dev. 2021, 35(3-4): 261-272. PMID: 33446573

9. Wan B, Wu J, Meng X, Lei M, Zhao X. Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Mol Cell. 2019, 75(2):238-251. PMID: 31348879.

10. Bonner JN, Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X. Smc5/6 mediated sumoylation of the Sgs1-Top3-Rmi1 complex promotes removal of recombination intermediates. Cell Rep. 2016,16(2):368-378. PMID: 27373152.

11. Yin J#, Wan B#, Sarkar J#, Horvath K, Wu J, Chen Y, Cheng G, Wan K, Chin P, Lei M*, Liu Y*. Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex. Nucl Acids Res. 2016,44(10):4871-4880. PMID: 27131364 (# equal contribution)

12. Wan B#, Tang T#, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J*, Lei M*. The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex. Nat Struct Mol Biol. 2015,22(12):1023-1026. PMID: 26551074. (# equal contribution)

13. Sarkar J, Wan B, Yin J, Vallabhaneni H, Horvath K, Kulikowicz T, Bohr VA, Zhang Y, Lei M, Liu Y. SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates. Nucl Acids Res. 2015,43(12):5912-5923. PMID: 25990736.

14. Yang YW, Flynn RA, Chen Y, Qu K, Wan B, Wang KC, Lei M, Chang HY. Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. Elife. 2014, 3:e02046. PMID: 24521543.

15. Sommers JA, Banerjee T, Hinds T, Wan B, Wold MS, Lei M and Brosh RM. Novel function of the fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein a-stimulated manner. J Biol Chem. 2014,289(29):19928-19941. PMID: 24895130.

16. Wan B#, Yin J#, Horvath K#, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y*, Lei M*. SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep. 2013,4(5):861-869. PMID: 24012755. (# equal contribution)

17. Zhou J, Wan B, Shan J, Shi H, Li Y, Huo K. PTPN4 negatively regulates CrkI in human cell lines. Cell Mol Biol Lett. 2013,18(2):297-314. PMID: 23666597.

18. Huang J, Gurung B#, Wan B#, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X, Lei M. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 2012,482(7386):542-546. PMID: 22327296. (# equal contribution)

19. Chen Y, Cao F, Wan B, Dou Y, Lei M. Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30. Cell Res. 2012,22(3):598-602. PMID: 22231628.

20. Huang J, Wan B, Wu L, Yang Y, Dou Y, Lei M. Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. Cell Res. 2012,22(6):1078-1081. PMID: 22547026.

21. Chen Y#, Wan B#, Wang KC#, Cao F, Yang Y, Protacio A, Dou Y, Chang HY, Lei M. Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. EMBO Rep. 2011,12(8):797-803. PMID: 21660059. (# equal contribution)

22. Xu X, Liu RF, Wan BB, Xing WM, Huang J, Han ZG. Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines. Mol Cell Biochem. 2011,354(1-2):11-20. PMID: 21461611.

23. Huang J, Zheng DL, Qin FS, Cheng N, Chen H, Wan BB, Wang YP, Xiao HS, Han ZG. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J Clin Invest. 2010,120(1):223-241. PMID: 20038795.

24. Wan B, Wang XR, Zhou YB, Zhang X, Huo K, Han ZG. C12ORF39, a novel secreted protein with a typical amidation processing signal. Biosci Rep. 2010,30(1):1-10. PMID: 19193193.

25. Li T, Wan B, Huang J. Comparison of gene expression in hepatocellular carcinoma, liver development and liver regeneration. Mol Genet Genomics. 2010,283(5):485-492. PMID: 20358383.

26. Wan B, Zhou YB, Zhang X, Zhu H, Huo K, Han ZG. hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro. FEBS Lett. 2008,582(21-22):3185-3192. PMID: 18708057.

27. Zhou YB#, Cao JB#, Wan BB#, Wang XR, Ding GH, Zhu H, Yang HM, Wang KS, Zhang X, Han ZG. hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence. Mol Cell Biochem. 2008,317(1-2):61-68. PMID: 18548201. (# equal contribution)

28. Li L, Shi Y, Wu H, Wan B, Li P, Zhou L, Shi H, Huo K. Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. Mol Cell Biochem. 2007,304(1-2):297-304. PMID: 17541814.

（Grants:）
1. 2022.01-2025.12 国家自然科学基金委面上项目：32170087 (DNA损伤修复方向)，在研，主持
2. 2023.01-2025.12开云网页登录 “交大之星”计划医工交叉研究基金，YG2023QNB11，在研，共同主持
3. 2025.06-2028.05 宁波市“科创甬江2035”重点研发计划项目，2025Z101，在研，参与
4. 2022.04-2025.03 上海市科委自然科学基金面上项目：22ZR1432700 (端粒方向)，在研，主持
5. 2022.03-2027.03开云网页登录 产学研合作项目：新一代测序酶的研制 (22H010100767) ，在研，主持
6. 2021.07-2023.07 转化医学国家重大基础设施（上海）开放课题：TMSK-2021-132 (DNA损伤修复与乳腺癌方向)，在研，主持
7. 2021.01-2026.12 开云网页登录 “双一流”建设高层次人才计划科研项目：BRCT结构域对基因组稳定性维持的分子机制研究，在研，主持
8. 2021.01-2026.12 开云网页登录 产学研合作项目：新一代高性能DNA 聚合酶研发项目 (21H010102507)，在研，主持

此外还受上海市海外高层次人才计划项目资助。

已授权专利 (Patents):
1. 中国专利授权公开号：CN113481229A，一种获得大肠杆菌超级感受态细胞的制备方法。曲红金，吕妍，万兵兵，曹禺，汪子喻，李俊实
2. 中国专利授权公开号：CN101003805A，人C10ORF58基因、其编码蛋白及应用。 韩泽广，万兵兵，黄健

(Lab members:)

博士后 Post-doc：
刘建康（2024级，毕业于清华大学）

留学生 Oversea student：
Aroosa Ijaz （2024级，毕业于University of the Punjab）

博士生 PhD Student：
曹禺（2021级，毕业于大连理工大学），胡黎明（2022级，毕业于兰州大学），罗思敏（2023级，毕业于开云网页登录 医学院），罗洋（2024级，获开云app官网入口下载苹果版 一等新生奖学金，毕业于四川大学）

硕士生Master Student：
白永亮（2022级，毕业于山东大学）
杨泽宇 （2024级，毕业于华东理工大学）
陈书阳 （2025级，毕业于华中农业大学）
曲奕帆 （2025级，毕业于青岛大学）

本科生 Undergrad：
郑雅文（开云网页登录 2022级）
赵苑羽（开云网页登录 2022级）

本科实习生 Intern：
Teresa Chai （西班牙Universidad Alcalá de henares）
Sinka Li （加拿大Western University）

已毕业Alumni：

黄逸飞（2021，现在澳大利亚The University of Queensland读博）
曲红金（2021级博士后，获开云网页登录 “晨星”博士后激励计划资助，毕业于海军军医大学），现担任生物技术公司联合创始人。
谢文俊（2021级硕士生，毕业于中山大学），现就职于深圳智能穿戴公司。
陈承诚（2024，毕业于英国UCL大学，现在新西兰University of Queensland读博）
陈燕（2022级硕士生，毕业于厦门大学），现就职于深圳医药国企。
刘帝成（开云网页登录 2021级），现保送交大直博。

计划招聘一名助理研究员/副研究员，招收博士研究生，硕士研究生，博士后若干名。
(Now, Wan Lab has 1 postdoctoral research fellow, 1 oversea student, 4 PhD candidate students, 4 Master student of SJTU. Wan Lab is planning to recruit 1 assistant/associate investigator and more graduate students from China or abroad.)