Lei Li

  • Tel: +86 021
  • Email: lei.li@sjtu.edu.cn
  • Address: 800 Zhangjiali RD. Minhang District, Shanghai, China
  • Tenure-track associate professor, group leader. Our team focuses on chemical biology and synthetic biology of microbial natural products, including high-throughput (meta)genomic mining of bioactive compounds and system metabolic engineering of industrial microorganisms driven by novel synthetic biology approaches.

Selected Publications

  • Li L*, Zhou YW, Wu YZ. Identification of a pair of linear or cyclic naturally inspired bifunctional lipopeptide antibiotics that overcome antimicrobial resistance.Advanced Science2025; e09796.

    Zhang F#, Zhang F#, Yu XC#, Sun RZ, Wu YZ, Zhou YW, Li L*. Discovery of a novel family of Gram-negative-active cationic cyclolipopeptides by motif search-guided chemical synthesis.CCS Chemistry2025; 7:2441-2450.

    Sun RZ#, Zhao D#, Yu XC#, Zhang F, You RX, Luo XX, Li L*. Discovery of a family of menaquinone-targeting cyclic lipodepsipeptides for multidrug-resistant Gram-positive pathogens.Communications Biology2024; 7:1453.

    Sun RZ, You RX, Yu XC, Zhao D, Li L*. Discovery and synthesis of a Gram-negative-active cationic lipopeptide antibiotic inspired by primary sequences from underexplored Gram-negative bacteria.Organic Letters2024; 26:1348-1352.

    Li L, Koirala B, Hernandez Y, MacIntyre LW, Russo R, Ternei MA, Brady SF*. Identification of structurally diverse menaquinone-binding antibiotics within vivoactivity against multidrug-resistant pathogens.Nature Microbiology2022; 7:120-131.

  • Zhang F#, Zhao D#, Wu YZ#Li L*. Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity.Natural Product Reports2025; 42:1303.

    Li L*. Accessing hidden microbial biosynthetic potential from underexplored sources for novel drug discovery.Biotechnology Advances2023; 66:108176.

    Li L, Wei KK, Liu XC, Wu YJ, Zheng GS, Chen SX, Jiang WH*, Lu YH*. aMSGE: advanced multiplex site-specific genome engineering with orthogonal modular recombinases in actinomycetes.Metabolic Engineering2019; 52:153-167.

    Li L, Zheng GS, Chen J, Ge M, Jiang WH*, Lu YH*. Multiplexed site-specific genome engineering for overproducing bioactive secondary metabolites in actinomycetes.Metabolic Engineering2017; 40:80-92.

    Li L, Zhao YW, Ruan LJ, Yang S, Ge M, Jiang WH*, Lu YH*. A stepwise increase in pristinamycin II biosynthesis byStreptomyces pristinaespiralisthrough combinatorial metabolic engineering.Metabolic Engineering2015; 29:12-25.

Students

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