Tenure-track Associate Professor
Education background
Supervisors: Dr. Prof. Jian-He Xu, Dr. Prof. Jiahai Zhou
Bioengineering School
East China University of Science & Technology, China
Shanghai Institute of Organic Chemistry, China
Supervisors: Dr. Prof. Jian-He Xu, Dr. Jiang Pan
Bioengineering School
East China University of Science & Technology, China
Appointment
School of Life Sciences and Technology
Shanghai Jiao Tong University, China
Supervisor: Dr. Prof. Christian Heinis
Laboratory of Therapeutic Proteins and Peptides
Institute of Chemical Sciences and Engineering
EPFL, Switzerland
Protein fitness landscape analysis based on phage display and next-generation sequencing techniques.
Improve bioavailability of peptide drugs by the evolution of peptide stability and permeability.
Guo, Q.; Zeng, H.;Kong, X.D.#Phage Selection of Cyclic Peptides Inhibiting Aminoglycoside Phosphotransferases to Control Resistant Bacteria.ACS Chem. Biol.2025, 20, 2219−2228.
Ma, B.D.; Li, J.Y.; Xu, J.H.; Yu, T.;Kong, X.D.#ADP-ribose is a competitive inhibitor of methanol dehydrogenases from Bacillus methanolicus.J. Biol. Chem.2025, 110599.
Han, Y., Luo, Y., Ma, B.D., Li, J.#, Xu, J.H.#andKong, X.D.#Structural Insights of a cis-Epoxysuccinate Hydrolase Facilitate the Development of Robust Biocatalysts for the Production of l-(+)-Tartrate.Biochem., 2024, doi:10.1021/acs.biochem.4c00141
Zhu, X.X., Zheng, W.Q., Xia, Z.W., Chen, X.R., Jin, T., Ding, X.W., Chen, F.F., Chen, Q., Xu, J.H.Kong, X.D.#and Zheng, G.W.#Evolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction.Nat. Commun., 2024, 15, 10330.
Sun, C.*, Ma, B.D.*, Li, G., Tian, W., Yang, L., Peng, H., Lin, Z., Deng, Z.,Kong, X.D.#and Qu, X.#Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines.Angew Chem. Int. Ed., 2023, e202304994.
Kong, X.D., Carle, V., Díaz-Perlas, C., Butler, K., Heinis, C.#Generation of a large peptide phage display library by self-ligation of whole-plasmid PCR product.ACS Chem. Biol., 2020, 15, 2907–2915.
Kale, S.S.*, Villequey, C.*,Kong, X.D.*, Zorzi, A., Deyle, K., Heinis, C#. Cyclization of peptides with two chemical bridges affords large scaffold diversities.Nat. Chem., 2018, 10, 715-723.
Kong, X.D., Moriya, J., Carle, V., Pojer, F., Abriata, L.A., Deyle, K., Heinis, C. De novo development of proteolytically resistant therapeutic peptides for oral administration.Nat. Biomed. Eng., 2020, 4, 560–571.
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