THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
2017
T-cell lymphomasare aggressive diseases associated with poor outcome. Here, the authors show that the THZ1, a CDK7 inhibitor, suppresses
STATtranscriptional activity leading to apoptosis and sensitization to BCL2 inhibitors in
T-cell lymphomas.
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