Bevacizumab and capecitabine in relapsed platinum-resistant epithelial carcinoma of ovary: A retrospective study
2019
Background: Relapsed platinum-resistant epithelial carcinoma of the
ovaryis a disease with a dismal prognosis.
Bevacizumaband
capecitabinehave been used in carcinoma of
ovaryboth as a single agent and with other chemotherapeutic medicine. A retrospective study has been performed to assess the efficacy of
bevacizumab+
capecitabinein relapsed platinum-resistant epithelial carcinoma of the
ovary. Materials and Methods: Patients who suffered from relapsed platinum-resistant epithelial carcinoma of the
ovaryand received
bevacizumaband
capecitabinewere included in the present study. The primary objective of this study was to assess response rate and progression-free survival (PFS). Treatment: Patients received
capecitabineat a dose of 1250 mg/m2 twice daily from day 1 to day 14 in each cycle.
Bevacizumabwas given at a dose of 7.5 mg/kg on day 1 in each cycle. The cycle was repeated in every 3 weeks. Response evaluation was done using the
Response Evaluation Criteriain
Solid Tumorcriteria and by Rustin criteria. Statistical Analysis: Statistical analysis was done using statistical software (SPSS 16, SPSS for Windows, SPSS Inc., Chicago, IL, USA). Results: We analyzed the data of 32 patients. The PFS was 10.51 (95% confidence interval [CI], 8.65–12.37) months. The overall survival (OS) was 20.53 (95% CI, 17.21–23.85) months. Four (12.5%) patients achieved complete response. Eighteen (56.25%) patients achieved partial response. The response rate was 68.75%. Four (12.5%) patients had progressive disease. Conclusion: Response rate, PFS, and OS of patients in this study are comparable to those of other published studies. Hence,
bevacizumab+
capecitabinecan be used in relapsed platinum-resistant carcinoma of the
ovary. The incidence and severity of
bevacizumab-induced side effects are relatively lower in this study. Hence,
bevacizumabcan be given at a lower dose with comparable efficacy and tolerable side effects.
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