Outcome of surgical and endoscopic lung volume reduction with valves in patients with severe lung emphysema: current data of 246 patients with 3 months follow-up from a Lung Emphysema Registry in Germany

Introduction: Lung emphysema is associated with high morbidity and mortality rates. Both surgical lung volume reduction (LVRS) and endoscopic lung volume reduction with valves (ELVR-V) seem to produce good clinical outcomes.However, a systematical comparison of different treatment approaches is still missing. The main goal of the Lung Emphysema Registry (LE-R) is to analyze types of treatment applied to patients with severe lung emphysema and to describe outcomes in relation to treatment techniques over time. Methods: The LE-R is a multicenter non-randomized prospective clinical study, which is collecting data exclusively on patients with lung emphysema treated at specialized centers. The patients were followed up after 3 months, and the lung function (FEV1, RV, VC, DLCO), the clinical status, quality of life (CAT and mMRC) and exercise capacity (6-MWT) were documented. Results: Since 2017 246 patients were included. Table 1 displays improvements in lung function and quality of life in both groups at 3mo FU. Conclusions: These novel findings suggest that both techniques are beneficial to patients with severe emphysema up to 3 months after intervention in a real-world observational study. Future analyses might help to define which treatment types should be applied to the specific patients subgroups.