Inactivation of Capicua drives cancer metastasis
2017
Trever Bivona and colleagues use an in vivo lung cancer
metastasismodel to show that the transcriptional
repressorCapicua (
CIC) suppresses invasion and
metastasis.
CICinactivation leads to upregulation of ETV4 and MMP24, which is necessary and sufficient for
metastasis.
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