Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics

Oksana Tyshchuk,Christoph Gstöttner,Dennis Funk,Simone Nicolardi,Stefan Frost,Stefan Klostermann,Tim Becker,Elena Jolkver,Felix Schumacher,Claudia Ferrara Koller,Hans Rainer Völger,Manfred Wuhrer,Patrick Bulau,Michael Molhoj

Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics

2019

Oksana Tyshchuk
Christoph Gstöttner
Dennis Funk
Simone Nicolardi
Stefan Frost
Stefan Klostermann
Tim Becker
Elena Jolkver
Felix Schumacher
Claudia Ferrara Koller
Hans Rainer Völger
Manfred Wuhrer
Patrick Bulau
Michael Molhoj

ABSTRACTBiotherapeutics may contain a multitude of different post-translational modifications (PTMs) that need to be assessed and possibly monitored and controlled to ensure reproducible product qu...

Keywords:

Hydroxyproline
Molecular biology
Biology
Posttranslational modification
Biochemistry
Chinese hamster ovary cell
Sulfotyrosine

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