Abstract 3891: Tolerability and outcomes of trametinib and everolimus combinations in advanced solid tumors

Purpose Aberrations in the PI3K/AKT/mTOR and MAPK pathways are routinely found in patients with cancer. To date, safe and effective combinations of drugs that hit both pathways concurrently are scarce. Data from Tolcher and colleagues have shown that the combination of trametiniband everolimusis intolerable at the doses and schedules studied in a phase 1 trial for patients with advanced solid tumors. The purpose of this analysis was to determine the tolerability and outcomes for patients prescribed trametiniband everolimusutilized in 2 open trials at our center. Methods A retrospective analysis was performed on 31 patients with various tumor types at the Avera Cancer Institute with approval from the IRB. Patients who received at least one dose of trametinibin combination with everolimusin addition to concurrent therapies were included. Fifteen patients (48%) had undergone ≥ three lines of therapy prior to initiation of trametiniband everolimus. Descriptive statistics were used to determine primary and secondary outcomes. Tolerability was defined as number of dose adjustments or holds in therapy for each regimen. Primary outcome was based on comparisons between tolerability of the drug regimens and the schedule of doses, line of therapy, concurrent cytotoxic agents, and primary tumor type. A secondary outcome calculated the PFS of eligible patients (n=5) who had different trametiniband everolimusregimens. Results Twenty-three patients (74%) tolerated various combinations of trametiniband everolimus, of which 16 received treatment for more than 3 months. Eight patients (26%) discontinued treatment due to adverse events, of which six patients did so within the first 3 months of treatment. Average time to first hold or reduction in therapy due to toxicities from any trametiniband everolimusregimen was 2.5 months. Most common adverse events were fatigue (n=19), mucositis (n=18), and elevated LFT9s (n=17). The most common regimen utilized (n=23) was initiated at trametinib1 mg daily with everolimus5 mg every Mon, Wed, Fri. Patients on this regimen experienced dose-limiting toxicities at an average of 1.4 months after initiation. Trametiniband everolimuswere most commonly started as ≥ the fourth line of therapy. PFS for evaluable patients was 6.5 months; two patients continue to respond. PIK3CA (n=10) and KRAS (n=9) were the most common mutations identified. Conclusion In this analysis, the combination of trametiniband everolimushas shown to be tolerable in many patients with advanced solid tumors, and has also demonstrated clinical efficacy for patients with heavily pre-treated disease. However, the regimens utilized were highly individualized, thus notable variability existed between patient therapies. Therefore, to determine an optimal dose and schedule to evaluate the overall efficacy of trametiniband everolimuscombination, an adequately powered and controlled study would be required. Citation Format: Jason Patterson, CoryPerry, Joe Windscheffel, Rachel Elsey, Kirstin Williams, Nandini Dey, Pradip De, Brian Leyland-Jones, Casey Williams. Tolerability and outcomes of trametiniband everolimuscombinations in advanced solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3891.