Complete eradication of chronic lymphocytic leukemia with unusual skin involvement of high mitotic index after 12 cycles of Venetoclax/obinutuzumab

A 51-year male patient presented with large skin masses of the chest wall that were pathologically proven to be chronic lymphocytic leukemia/small lymphocytic lymphoma(CLL/SLL) with Ki67:70%. The patient was treated with the time-limited Venetoclax/Obinutuzumab combination for 12 cycles and CLL/SLL including the skin component was set in complete remission.