Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer
2019
Background Preclinical studies demonstrate synergism between
cancer immunotherapyand local radiation, enhancing anti-tumor effects and promoting immune responses. BI1361849 (CV9202) is an active cancer immunotherapeutic comprising
protamine-formulated, sequence-optimized mRNA encoding six non-small cell lung cancer (NSCLC)-associated antigens (
NY-ESO-1, MAGE-C1, MAGE-C2,
survivin, 5T4, and MUC-1), intended to induce targeted immune responses.
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